Med29 Activators
Med29 Activators are a collection of chemical compounds that influence the function of Med29, a protein critical in signal transduction as part of the Mediator complex. These activators, including Forskolin, IBMX, Epinephrine, Dopamine, Isoproterenol, Adenosine, Rolipram, PGE2, Glucagon, Cilostamide, Salmeterol, and Terbutaline, work through a common pathway involving cAMP and PKA. The elevation of cAMP levels, either through direct activation of adenylate cyclase, inhibition of phosphodiesterase, or receptor-mediated processes, leads to the activation of protein kinase A (PKA). PKA is known to phosphorylate Med29, enhancing its functional activity.
Each of these Med29 Activators plays a unique role in elevating cAMP levels. For instance, Forskolin directly activates adenylate cyclase, increasing cAMP levels, while IBMX, Rolipram and Cilostamide inhibit different types of phosphodiesterase, preventing the breakdown of cAMP. Compounds such as Epinephrine, Isoproterenol, Adenosine, PGE2, Glucagon, Salmeterol, and Terbutaline increase cAMP levels through receptor-mediated processes. Despite their diverse mechanisms of action, all these compounds ultimately enhance the functional activity of Med29 throughthe activation of PKA via the elevation of cAMP levels. This common pathway underscores the fundamental role of cAMP and PKA in the regulation of Med29, and the diverse mechanisms through which these activators function highlight the intricacy of cellular signaling involved in the regulation of this protein. The subsequent phosphorylation of Med29 by PKA signifies an enhanced functional state of the protein, integral to its role in the Mediator complex. Med29 forms part of this larger protein complex that acts as a bridge between DNA-bound transcription factors and RNA polymerase II, thus playing a crucial role in transcription regulation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Higher cAMP levels can enhance the activity of protein kinase A (PKA), which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterase, which results in increased levels of cAMP. The elevation of cAMP can activate PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to and activates beta-adrenergic receptors, leading to an increase in cAMP. The resultant cAMP then activates PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, through D1-like receptors, can increase the levels of cAMP. This, in turn, can activate PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol binds to and activates beta-adrenergic receptors, causing an increase in cAMP levels. The elevated cAMP activates PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine, through A2a receptors, can increase cAMP levels. The increased cAMP activates PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase-4, leading to increased cAMP levels. The elevation in cAMP activates PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) can activate EP2 and EP4 receptors, leading to an increase in cAMP levels. The increased cAMP activates PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide is a selective inhibitor of phosphodiesterase-3, leading to an increase in cAMP levels. The increased cAMP can activate PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||
Salmeterol | 89365-50-4 | sc-224277 sc-224277A | 10 mg 50 mg | $186.00 $562.00 | 1 | |
Salmeterol is a long-acting beta2-adrenergic receptor agonist that increases cAMP levels. The elevated cAMP can activate PKA, which is known to phosphorylate Med29, thereby enhancing its functional activity. | ||||||