MDM1 Activators
MDM1 activators are chemicals that can either directly or indirectly enhance the activity or localization of MDM1, a microtubule-binding nuclear protein essential for centriole duplication. One of the most significant pathways that MDM1 is involved in is the regulation and interaction with microtubules. Many of the listed chemicals target microtubule dynamics either by stabilizing or destabilizing them.
Paclitaxel and Epothilone B, for instance, function by stabilizing microtubules, thus their depolymerization. An environment with stabilized microtubules might enhance MDM1's association with these structures. In contrast, agents like Colchicine, Nocodazole, and Vinblastine disrupt microtubules by inhibiting their polymerization or directly binding to tubulin units. These agents create a cellular environment where microtubule dynamics are altered, which can indirectly influence MDM1's activity or its localization to the centrioles. Moreover, chemicals like Podophyllotoxin and Combretastatin A-4 further exemplify the diversity of molecules that interact with the microtubule network. Each has its unique mechanism, but all can modify MDM1's function through their impact on microtubules. The intricate dance between microtubule dynamics and proteins like MDM1 emphasizes the delicate balance required for cellular processes such as centriole duplication and cell division. Thus, understanding how these chemicals influence MDM1 can provide insights into the broader context of cell cycle regulation and cellular architecture maintenance.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization. Given that MDM1 binds to microtubules, paclitaxel may enhance its association and possibly its activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds tubulin and inhibits microtubule polymerization. This action can modify the microtubule dynamics and indirectly affect proteins like MDM1 that associate with microtubules. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules by binding to β-tubulin. Changes in microtubule dynamics may indirectly modulate MDM1's association and function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds tubulin, inhibiting microtubule formation. Alteration in microtubule dynamics can potentially modify MDM1's activity or localization. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules in a similar manner to paclitaxel. Enhanced microtubule stability can indirectly influence proteins like MDM1 that are associated with microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits microtubule polymerization by binding to tubulin. Changes in microtubule structure and dynamics can indirectly affect MDM1's function. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin A-4 binds to tubulin, leading to microtubule depolymerization. Such alterations in microtubule dynamics can have downstream effects on MDM1's function or localization. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide promotes microtubule assembly and stabilizes microtubules. Given MDM1's association with microtubules, enhanced microtubule stability might indirectly affect MDM1. | ||||||
Maytansine | 35846-53-8 | sc-507510 | 100 mg | $1000.00 | ||
Maytansine inhibits microtubule assembly. The modification in microtubule dynamics, as a result, can potentially influence proteins associated with microtubules, like MDM1. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with polymerized microtubules. This alteration can influence proteins that associate with microtubules, potentially affecting MDM1. | ||||||