MDM1 Inhibitors
MDM1 inhibitors are chemicals that can reduce the activity or alter the localization of MDM1, a nuclear protein crucial for centriole duplication through its interaction with microtubules. Many of the chemicals in this category target proteins and processes that, in turn, have roles in centriole duplication and spindle assembly. For example, compounds like Monastrol and S-Trityl-L-cysteine target the kinesin Eg5, leading to the disruption of bipolar spindle formation. Such alterations in spindle dynamics can indirectly affect MDM1's association with microtubules and its functionality. Similarly, inhibitors like Alisertib target kinases like Aurora A, which are essential for processes related to centriole duplication.
Further, PLK1 inhibitors like BI 2536 and Rigosertib highlight the intricacies of the centriole duplication process. Polo-like kinase 1 (Plk1) is essential for centrosome maturation, and its inhibition can provide insight into how other proteins, including MDM1, are affected within this context. The cellular processes surrounding centriole duplication are intricate, with many proteins playing interdependent roles. By understanding how these chemicals affect such processes, it becomes clearer how they might influence MDM1's activity, either directly or indirectly. These inhibitors, therefore, offer a window into the complex world of centriole duplication and the proteins that govern it.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a small molecule inhibitor of the kinesin Eg5, disrupting bipolar spindle formation. By targeting spindle dynamics, it can indirectly affect MDM1 localization and function during centriole duplication. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib targets the Aurora A kinase, an enzyme critical for centrosome maturation and separation. Inhibiting Aurora A can indirectly disrupt MDM1 function in centriole duplication. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a cyclin-dependent kinase inhibitor. CDKs play roles in centriole duplication, and their inhibition can indirectly affect proteins involved in this process, such as MDM1. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is another inhibitor of cyclin-dependent kinases. By modulating CDK activity, it can influence proteins involved in centriole duplication, potentially affecting MDM1 indirectly. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a potent inhibitor of Polo-like kinase (Plk1), which plays a pivotal role in centrosome maturation. Inhibition of Plk1 can indirectly interfere with MDM1's role in centriole duplication. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of Eg5, which can lead to monopolar spindle formation. Given MDM1's association with microtubules, disrupting spindle formation can indirectly affect MDM1. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $218.00 $905.00 | 7 | |
AZ3146 is an inhibitor of Mps1, a kinase involved in spindle assembly checkpoint. Disruption of this checkpoint can indirectly influence MDM1's function in centriole duplication. | ||||||
Eg5 Inhibitor III, Dimethylenastron | 863774-58-7 | sc-221576 sc-221576A sc-221576B sc-221576C | 1 mg 5 mg 10 mg 25 mg | $38.00 $132.00 $244.00 $516.00 | 1 | |
Dimethylenastron is another inhibitor of kinesin Eg5. By affecting spindle dynamics, it can indirectly modulate MDM1's function or localization. | ||||||
Reversine | 656820-32-5 | sc-203236 | 5 mg | $221.00 | 13 | |
Reversine is an inhibitor of Mps1 and Aurora kinases. Its action on these kinases can potentially influence the function or localization of proteins involved in centriole duplication, like MDM1. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 targets Aurora kinases, key players in centrosome and spindle function. Inhibition of these kinases can disrupt MDM1's role in centriole duplication. | ||||||