Reversine (CAS 656820-32-5)
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Reversine is a cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Reversine is shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 µM. Reversine is also the first organic molecule that has been demonstrated to reverse the cellular differentiation process. The compound acts as a selective A3 adenosine receptor antagonist (Ki= 660 nM, >10 µM, and >10 µM for hA3, hA1, and hA2A, respectively. Reversine functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). The compound also acts as an ATP-competitive, reversible and selective inhibitor of Aurora Kinases A, B and C (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel.
Reversine (CAS 656820-32-5) References
D'Alise, A.M., et al. 2008. Mol. Cancer Ther. 7, 1140. Chen, S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 10482. Perreira, M., et al. 2005. J. Med. Chem. 48, 4910. Chen, S., et al. 2004. J. Am. Chem. Soc., 126, 410.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reversine, 5 mg | sc-203236 | 5 mg | $221.00 |