MD-1 Activators
MD-1 Activators encompass a diverse array of chemical compounds that facilitate the enhancement of MD-1's functional activity through distinct signaling pathways. Forskolin, by stimulating adenylate cyclase, raises cAMP levels which in turn activates PKA; this activation chain can lead to the phosphorylation and subsequent enhancement of MD-1's function. Similarly, Piperine's inhibition of cAMP-degrading enzymes also results in increased PKA activity, potentially leading to MD-1 activation. Curcumin and CAPE, both through their inhibitory effects on NF-kB, release the suppression of MD-1, enabling its active participation in immune signaling. Resveratrol's activation of SIRT1 may lead to deacetylation of components within MD-1's pathway, thereby amplifying its role, while Quercetin and EGCG, by inhibiting PI3K and other kinases respectively, could lift inhibitory constraints on MD-1, improving its functional activity.
Moreover, compounds like Sulforaphane, through Nrf2 pathway activation, and 6-Gingerol, by modulating inflammatory pathways, present potential enhancement of MD-1 activity, especially in oxidative and inflammatory responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins, including MD-1, thereby enhancing its function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate transcription factors such as NF-kB, which is involved in the expression and regulation of immune response genes. By inhibiting NF-kB, curcumin may reduce the repression of MD-1, leading to its enhanced activity in immune signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which in turn can deacetylate proteins and influence pathways affecting MD-1 activity, especially in inflammatory processes. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine inhibits enzymes that can degrade cAMP, thus indirectly increasing its levels and enhancing PKA activity, which could phosphorylate MD-1 and increase its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits phosphoinositide 3-kinases (PI3K), which may result in altered signaling pathways that enhance MD-1 function, particularly in its role as a modulator in immune responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits multiple kinases, which may relieve negative regulation on MD-1, thereby promoting its activity within immune signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which can lead to the upregulation of antioxidant response elements and potentially enhance the activity of MD-1 in oxidative stress responses. | ||||||
Gingerol | 23513-14-6 | sc-201519 sc-201519A | 5 mg 20 mg | $107.00 $379.00 | 5 | |
6-Gingerol has been shown to modulate inflammatory pathways, which could result in the functional activation of MD-1 within these pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1 receptors, which can lead to a cascade of signaling events, including the activation of NF-kB and possibly enhancing the activity of MD-1 in immune response. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
CAPE inhibits NF-kB, potentially reducing the repression on MD-1 activity and thus enhancing its role in immune signaling pathways. | ||||||