MCT12 Inhibitors
MCT12 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the Monocarboxylate Transporter 12 (MCT12), also known as SLC16A12. MCT12 is a member of the solute carrier family 16, which is involved in the transport of monocarboxylates across cell membranes. These transporters play a crucial role in the cellular uptake and efflux of metabolic intermediates, such as lactate, pyruvate, and other monocarboxylates, which are essential for various metabolic pathways. By inhibiting MCT12, researchers can explore the role of this transporter in cellular metabolism and its impact on physiological processes.
In scientific research, MCT12 inhibitors serve as valuable tools for investigating the regulatory mechanisms of monocarboxylate transport and the metabolic pathways they influence. These inhibitors allow scientists to study how the inhibition of MCT12 affects cellular metabolism, energy production, and the overall metabolic flux within cells. Additionally, MCT12 inhibitors can help elucidate the transporter's role in specific tissues and organs, particularly in relation to their metabolic demands and functional activities. For instance, understanding how MCT12 contributes to metabolic processes in tissues such as the kidney, where it is highly expressed, can provide insights into the organ-specific roles of monocarboxylate transporters. Overall, the use of MCT12 inhibitors in research enhances our comprehension of metabolic regulation and the intricate network of transporters that maintain cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lonidamine | 50264-69-2 | sc-203115 sc-203115A | 5 mg 25 mg | $105.00 $364.00 | 7 | |
Lonidamine directly inhibits SLC16A, blocking the transport of lactate and disrupting cellular metabolism. | ||||||
ACY-1215 | 1316214-52-4 | sc-507455 | 25 mg | $110.00 | ||
AZD3965 binds directly to SLC16A, making it a potent and selective inhibitor that blocks lactate transport. AZD3965 is a selective inhibitor of SLC16A and MCT2, hindering the transport of lactate and pyruvate across the plasma membrane. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Bumetanide, though primarily a diuretic, has been shown to inhibit SLC16A indirectly, likely by affecting associated cellular processes. | ||||||
Cabozantinib L-Malate Salt | 1140909-48-3 | sc-504572 | 10 mg | $270.00 | ||
AR-C155858 is a potent and selective inhibitor of MCT2. It inhibits lactate transport by blocking the MCT2 transporter, preventing lactate uptake by cells. | ||||||
Hydrazine sulfate | 10034-93-2 | sc-211599 sc-211599A | 5 g 100 g | $48.00 $68.00 | ||
Inhibits various aminotransferases, could interfere with SLC16A function by competitive inhibition. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Inhibits dihydrofolate reductase, could lead to accumulation of metabolites that indirectly inhibit SLC16A. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
A redox cycling agent, can modulate cellular redox states that might affect SLC16A activity. | ||||||
Phenethyl-hydrazine | 51-71-8 | sc-331686 | 500 mg | $396.00 | ||
A non-selective inhibitor of monoamine oxidase, could alter metabolic pathways related to SLC16A. | ||||||
Hydroxylamine solution | 7803-49-8 | sc-250136 | 100 ml | $72.00 | ||
General aminotransferase inhibitor, could inhibit SLC16A through covalent modification of the active site. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
The active form of Vitamin B6 and a cofactor for aminotransferases, its analogues can act as inhibitors for SLC16A. | ||||||