MCM3 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin, a platinum-based chemotherapeutic, acts as an indirect inhibitor of MCM3. By inducing DNA crosslinks and adducts, cisplatin disrupts DNA replication, indirectly impacting the function of MCM3, a key replicative helicase. This disruption leads to stalled replication forks and impedes the normal progression of the cell cycle, providing an indirect mechanism for inhibiting MCM3 and compromising cellular proliferation. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Also called Gemcitabine, this compound is an indirect inhibitor of MCM3 through its influence on DNA synthesis. As a nucleoside analogue, gemcitabine is incorporated into growing DNA chains during replication, causing chain termination and inhibiting DNA synthesis. This indirect inhibition disrupts the normal functioning of MCM3 by impeding the unwinding of DNA strands, contributing to cell cycle arrest and apoptosis. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a direct inhibitor of MCM3 and other replicative polymerases. By binding to the catalytic site of DNA polymerase α and preventing its interaction with the template DNA, aphidicolin directly inhibits DNA synthesis and unwinding, impeding the function of MCM3. This direct inhibition results in the formation of stalled replication forks and contributes to cell cycle arrest, providing a targeted approach to inhibit MCM3 and disrupt cellular proliferation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea (HU) is an indirect inhibitor of MCM3 through its impact on DNA replication. HU induces replication stress by inhibiting ribonucleotide reductase, leading to a reduction in the pool of deoxyribonucleotides required for DNA synthesis. This indirect inhibition disrupts the normal functioning of MCM3 by causing replication fork stalling and DNA damage, contributing to cell cycle arrest and apoptosis. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $48.00 $72.00 $265.00 $449.00 $1724.00 $112.00 | 16 | |
Thymidine is an indirect inhibitor of MCM3 by influencing DNA synthesis. As a nucleoside, thymidine competes with deoxythymidine triphosphate (dTTP) during DNA replication. This competition results in the slowing down of DNA synthesis and the formation of replication stress, indirectly inhibiting the function of MCM3. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin is an indirect inhibitor of MCM3 through its impact on DNA replication and topoisomerase II. By intercalating into DNA and inhibiting topoisomerase II, doxorubicin induces DNA damage and replication stress, indirectly inhibiting the function of MCM3. This disruption leads to the formation of stalled replication forks, DNA strand breaks, and cell cycle arrest, providing an indirect mechanism for inhibiting MCM3 and compromising cellular proliferation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a direct inhibitor of cyclin-dependent kinases (CDKs), including CDK2. By inhibiting CDKs, roscovitine disrupts the phosphorylation of MCM3 and other components of the pre-replication complex, directly inhibiting DNA replication initiation. This direct inhibition results in stalled replication forks and cell cycle arrest, providing a targeted approach to inhibit MCM3 and impede cellular proliferation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is an indirect inhibitor of MCM3 through its impact on topoisomerase II. By forming a complex with topoisomerase II and DNA, etoposide induces DNA strand breaks and replication stress, indirectly inhibiting the function of MCM3. This disruption leads to the formation of stalled replication forks, DNA damage, and cell cycle arrest, providing an indirect mechanism for inhibiting MCM3 and compromising cellular proliferation. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is an indirect inhibitor of MCM3 through its influence on DNA synthesis. As a fluorinated analogue of uracil, Fluorouracil is incorporated into RNA and DNA, leading to chain termination during replication. This indirect inhibition disrupts the normal functioning of MCM3 by impeding the unwinding of DNA strands and causing replication stress, contributing to cell cycle arrest and apoptosis. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is an indirect inhibitor of MCM3 through its impact on poly(ADP-ribose) polymerase (PARP). By inhibiting PARP, olaparib disrupts DNA repair mechanisms, inducing replication stress and DNA damage. This indirect inhibition compromises the function of MCM3 by contributing to stalled replication forks and cell cycle arrest, providing an indirect mechanism for inhibiting MCM3 and impeding cellular proliferation. | ||||||