MCFD2 Inhibitors
MCFD2 inhibitors are a collection of chemicals primarily targeting the ER-Golgi transport mechanisms and related cellular processes. Many of these compounds, such as Brefeldin A and Monensin, focus on disrupting the Golgi apparatus and its function. Others, including Thapsigargin and Tunicamycin, induce ER stress, which can indirectly impact the function of transport proteins like MCFD2.
The compounds in this category range from those that directly act on the vesicle transport machinery to those that indirectly affect the cellular environment in which these transport processes occur. For example, Nocodazole's destabilization of microtubules can impede the physical infrastructure that supports vesicle transport. In contrast, agents like Forskolin elevate cAMP levels, disrupting vesicle trafficking through intracellular signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts the Golgi apparatus by inhibiting ADP-ribosylation factor (ARF). This disruption can impede ER-Golgi transport dynamics, potentially leading to changes in the activity of proteins like MCFD2 involved in this process. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Ionophore that interferes with the Golgi pH gradient and hampers transport between the ER and Golgi. By disturbing Golgi function, it can modulate proteins, including MCFD2, associated with vesicle transport. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules. Given that microtubules maintain Golgi structure and support vesicle transport, their destabilization can influence ER-Golgi transport and, by extension, proteins like MCFD2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inducer of ER stress by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). The elevated ER stress can interfere with the ER-Golgi transport system, possibly affecting the activity of MCFD2. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress by inhibiting N-linked glycosylation. The resulting unfolded protein response can interfere with the ER-Golgi transport system, indirectly affecting MCFD2's function. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Inhibits ER-associated degradation (ERAD) and causes ER stress. Elevated ER stress can impact the ER-Golgi transport machinery and, in turn, proteins like MCFD2 associated with this pathway. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
V-ATPase inhibitor that acidifies intracellular vesicles, affecting vesicle trafficking and fusion. This can interfere with the normal ER-Golgi transport, impacting proteins like MCFD2. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Cationic amphiphilic drug known to disrupt lysosomal function, which can interfere with vesicle trafficking. This disruption might indirectly modulate the activity of ER-Golgi transport proteins, including MCFD2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP can disrupt vesicle trafficking, possibly influencing proteins like MCFD2, which are part of the transport machinery between the ER and Golgi. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $89.00 $288.00 | 1 | |
Disrupts the recycling of endosomes to the plasma membrane. By interfering with endosomal trafficking, it might indirectly affect proteins associated with the ER-Golgi transport system, including MCFD2. | ||||||