Maspin Inhibitors
Maspin inhibitors are a group of compounds that, through various mechanisms, can lead to a reduction in Maspin activity. They may function by altering the epigenetic status of the Maspin gene, such as through DNA methylation or histone modification, which can repress Maspin expression. For example, while agents like 5-Aza-2'-deoxycytidine and hydralazine are typically used to reduce methylation, in some cases, they could lead to gene silencing depending on the cellular context.
Moreover, synthetic siRNA and miRNA mimics designed to target Maspin mRNA can directly lead to its degradation or inhibit its translation, effectively decreasing Maspin protein levels. Transcription and translation inhibitors, such as alpha-amanitin, actinomycin D, cycloheximide, and rapamycin, can prevent Maspin synthesis at different stages of gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor; however, at certain conditions, it may lead to hypermethylation and silencing of tumor suppressor genes like Maspin. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
An anticancer antibiotic that binds to DNA and could potentially inhibit transcription factors from binding to the Maspin promoter. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
A vasodilator that can demethylate DNA but might lead to gene silencing under specific conditions. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Histone deacetylase inhibitor, which in certain contexts, could lead to the repression of genes like Maspin. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor, under specific conditions, might repress certain genes. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
RNA polymerase II inhibitor that can prevent the transcription of Maspin. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Intercalates into DNA and can inhibit RNA synthesis, potentially decreasing Maspin expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis, potentially reducing Maspin protein levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that can suppress protein synthesis and might indirectly reduce Maspin levels. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Cyclin-dependent kinase inhibitor that may reduce transcription and thereby decrease Maspin expression. | ||||||