Date published: 2026-2-22

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MAPK1IP1L Activators

The chemical class referred to as MAPK1IP1L Activators encompasses a range of compounds that can activate the MAPK1IP1L protein, a component in the MAPK/ERK signaling pathway. These activators can initiate a cascade of events that lead to the modulation of MAPK1IP1L activity. The initiation usually begins at a receptor level, where ligands, such as growth factors, bind to receptor tyrosine kinases, which in turn trigger an intracellular signaling pathway involving phosphorylation events. This phosphorylation chain ultimately leads to the activation of MAPK1IP1L, as it is part of the intricate web of the MAPK/ERK pathway. The activators are not singular in their action but operate within the vast interconnectivity of cellular signaling networks. They serve as tools to manipulate specific signaling nodes that result in the activation of MAPK1IP1L, demonstrating the interconnected nature of cellular processes where altering one component can lead to changes in another.

The study and understanding of these activators rely on a deep knowledge of the MAPK/ERK pathway, as the activation of MAPK1IP1L is contingent on the proper functioning and regulation of this signaling route. Researchers utilize these activators to dissect the pathways, to understand the influence exerted by MAPK1IP1L within cellular contexts. This includes investigating how the activation of upstream components can lead to a series of phosphorylation events, and how these events can relay signals that result in the functional modulation of MAPK1IP1L. The precise mapping of these pathways allows for a clearer picture of the role MAPK1IP1L plays in cellular signaling. The activators serve as keys to unlock the mechanisms by which MAPK1IP1L can be regulated and are thus crucial in piecing together the signaling landscape where MAPK1IP1L is an integral component.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC), which can lead to activation of the MAPK/ERK pathway and could activate MAPK1IP1L.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 inhibits p38 MAPK, another MAPK pathway, which could activate MAPK1IP1L through cross-talk with the ERK pathway.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 inhibits JNK, part of the MAPK family, and could activate MAPK1IP1L via interactions with the MAPK/ERK pathway.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin activates adenylyl cyclase, which increases cAMP levels and can lead to PKA activation; this could activate MAPK1IP1L through cross-talk with the MAPK/ERK pathway.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor which can affect the MAPK/ERK pathway through cross-talk, and this could activate MAPK1IP1L.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, which is involved in cellular growth and proliferation, and could activate MAPK1IP1L through indirect pathway interactions.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a PI3K inhibitor that could affect MAPK1IP1L activity through its effects on downstream signaling pathways.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Anisomycin is a protein synthesis inhibitor that can activate MAPK pathways as a stress response, which could activate MAPK1IP1L.

Trametinib

871700-17-3sc-364639
sc-364639A
sc-364639B
5 mg
10 mg
1 g
$114.00
$166.00
$947.00
19
(1)

Trametinib is a MEK inhibitor, typically used as a therapeutic agent, which could be used to evaluate the modulation of MAPK1IP1L within the MAPK/ERK pathway.