Date published: 2026-4-1

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MAP-1B Inhibitors

MAP-1B inhibitors represent a class of chemical agents that specifically target and modulate the activity of Microtubule-Associated Protein 1B (MAP-1B), a protein integral to the stability and dynamics of the cytoskeleton in neuronal cells. MAP-1B is a member of the microtubule-associated proteins, which are known to play critical roles in microtubule stabilization, axonal growth, and neuronal plasticity. The inhibition of MAP-1B is of particular interest in studies related to the regulation of microtubule dynamics, as MAP-1B phosphorylation is linked to the destabilization of microtubules, leading to changes in cell morphology and motility. By inhibiting MAP-1B, researchers can explore the fundamental processes governing microtubule dynamics, cytoskeletal reorganization, and their broader implications in cell biology. At a molecular level, MAP-1B inhibitors may interfere with the interaction between MAP-1B and microtubules, thereby affecting microtubule stability and the intracellular transport processes that rely on these structures. This inhibition can lead to alterations in axonal transport, vesicle trafficking, and even synaptic plasticity, all of which are critical to understanding how cells communicate and adapt to environmental stimuli. Additionally, MAP-1B inhibition allows for the study of the post-translational modifications, such as phosphorylation, that MAP-1B undergoes and how these modifications influence its interaction with other proteins within the cell. By dissecting these molecular interactions, researchers can gain insights into the regulatory mechanisms that control cytoskeletal organization, offering a deeper understanding of the cellular architecture and its adaptability.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Taxol

33069-62-4sc-201439D
sc-201439
sc-201439A
sc-201439E
sc-201439B
sc-201439C
1 mg
5 mg
25 mg
100 mg
250 mg
1 g
$41.00
$74.00
$221.00
$247.00
$738.00
$1220.00
39
(2)

Taxol, an antineoplastic agent, stabilizes microtubules, influencing microtubule dynamics. MAP-1B, involved in microtubule dynamics, can be directly impacted, as Taxol stabilizes microtubules and alters their structure. Taxol's effect on microtubules can modulate MAP-1B function, potentially impacting cellular processes relying on microtubule dynamics.

Vinblastine

865-21-4sc-491749
sc-491749A
sc-491749B
sc-491749C
sc-491749D
10 mg
50 mg
100 mg
500 mg
1 g
$102.00
$235.00
$459.00
$1749.00
$2958.00
4
(0)

Vinblastine, an antineoplastic alkaloid, disrupts microtubule formation. MAP-1B, associated with microtubule dynamics, can be directly affected, as Vinblastine inhibits microtubule assembly. Vinblastine's interference with microtubule formation can modulate MAP-1B function, potentially impacting cellular processes reliant on proper microtubule organization.

Nocodazole

31430-18-9sc-3518B
sc-3518
sc-3518C
sc-3518A
5 mg
10 mg
25 mg
50 mg
$59.00
$85.00
$143.00
$247.00
38
(2)

Nocodazole, an antifungal agent, disrupts microtubule polymerization. MAP-1B, involved in microtubule dynamics, can be directly influenced, as Nocodazole inhibits microtubule assembly. Nocodazole's impact on microtubule polymerization can modulate MAP-1B function, potentially affecting cellular processes relying on dynamic microtubule structures.

Colchicine

64-86-8sc-203005
sc-203005A
sc-203005B
sc-203005C
sc-203005D
sc-203005E
1 g
5 g
50 g
100 g
500 g
1 kg
$100.00
$321.00
$2289.00
$4484.00
$18207.00
$34749.00
3
(2)

Colchicine, an alkaloid, inhibits microtubule polymerization. MAP-1B, associated with microtubule dynamics, can be directly affected, as Colchicine disrupts microtubule assembly. Colchicine's interference with microtubule polymerization can modulate MAP-1B function, potentially impacting cellular processes dependent on dynamic microtubule structures.

Epothilone B, Synthetic

152044-54-7sc-203944
2 mg
$176.00
(0)

Epothilone B, a microtubule-stabilizing agent, influences microtubule dynamics. MAP-1B, crucial for microtubule function, can be directly impacted, as Epothilone B stabilizes microtubules. Epothilone B's effect on microtubules can modulate MAP-1B function, potentially affecting cellular processes reliant on proper microtubule organization and dynamics.

Podophyllotoxin

518-28-5sc-204853
100 mg
$84.00
1
(1)

Podophyllotoxin, an antineoplastic lignan, inhibits microtubule assembly. MAP-1B, associated with microtubule dynamics, can be directly influenced, as Podophyllotoxin disrupts microtubule polymerization. Podophyllotoxin's impact on microtubules can modulate MAP-1B function, potentially affecting cellular processes reliant on dynamic microtubule structures.

Vinorelbine base

71486-22-1sc-205885
sc-205885A
sc-205885B
sc-205885C
sc-205885D
1 mg
5 mg
25 mg
100 mg
1 g
$29.00
$81.00
$260.00
$791.00
$1977.00
(0)

Vinorelbine, an antineoplastic vinca alkaloid, disrupts microtubule assembly. MAP-1B, involved in microtubule dynamics, can be directly affected, as Vinorelbine inhibits microtubule polymerization. Vinorelbine's interference with microtubule assembly can modulate MAP-1B function, potentially impacting cellular processes reliant on dynamic microtubule structures.

Griseofulvin

126-07-8sc-202171A
sc-202171
sc-202171B
5 mg
25 mg
100 mg
$85.00
$220.00
$598.00
4
(2)

Griseofulvin, an antifungal agent, disrupts microtubule function. MAP-1B, crucial for microtubule dynamics, can be directly influenced, as Griseofulvin interferes with microtubule function. Griseofulvin's impact on microtubules can modulate MAP-1B function, potentially affecting cellular processes reliant on proper microtubule organization and dynamics.

Colcemid

477-30-5sc-202550A
sc-202550
sc-202550B
sc-202550C
sc-202550D
sc-202550E
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
$68.00
$162.00
$318.00
$947.00
$1893.00
$6840.00
7
(1)

Colcemid, an alkaloid, inhibits microtubule assembly. MAP-1B, associated with microtubule dynamics, can be directly influenced, as Colcemid disrupts microtubule polymerization. Colcemid's impact on microtubules can modulate MAP-1B function, potentially affecting cellular processes reliant on dynamic microtubule structures.

Combrestatin A4

117048-59-6sc-204697
sc-204697A
1 mg
5 mg
$46.00
$81.00
(0)

Combretastatin A-4, a tubulin-binding agent, disrupts microtubule assembly. MAP-1B, crucial for microtubule dynamics, can be directly impacted, as Combretastatin A-4 interferes with microtubule polymerization. Combretastatin A-4's effect on microtubules can modulate MAP-1B function, potentially affecting cellular processes reliant on proper microtubule organization and dynamics.