MANEAL Activators
The term MANEAL Activators refers to a specific category of chemical compounds designed to modulate the activity of the MANEAL gene or protein. MANEAL, which stands for Mannosidase Endo-alpha-like, is a gene that encodes a protein with functional similarities to mannosidases, enzymes that play crucial roles in glycan processing and carbohydrate metabolism. The exact biological functions and regulatory mechanisms of MANEAL are subjects of ongoing research within the field of molecular biology and genetics. Activators within the MANEAL Activators class typically consist of small molecules or chemical agents strategically designed to interact with the MANEAL gene or protein, with the aim of enhancing its expression or influencing its functional capabilities. These activators serve as valuable tools for researchers to manipulate MANEAL-related processes and explore its potential functions in the context of glycan processing and cellular biology.
The mechanism of action for MANEAL Activators may involve various aspects of gene regulation or protein function. These compounds could influence the binding of transcription factors to the promoter region of the MANEAL gene, potentially increasing its transcriptional activity and leading to elevated MANEAL gene expression levels. Alternatively, they might affect the enzymatic activity or interactions of the MANEAL protein within the cellular glycan processing machinery, modulating its role in glycosylation reactions or glycan trimming. Researchers and scientists employ MANEAL Activators in molecular and cellular biology studies to investigate the roles of MANEAL in glycan processing and potential implications in normal cellular physiology. By selectively modulating the gene's activity or protein function, researchers can gain insights into its functions, regulatory mechanisms, and potential involvement in various cellular pathways, contributing to a deeper understanding of the molecular processes involving MANEAL and its significance in cellular biology. Overall, MANEAL Activators provide valuable tools for exploring the functions and regulatory mechanisms of this gene and protein in the context of glycan processing and carbohydrate metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, inducing ER stress and potentially upregulating MANEAL as part of the unfolded protein response (UPR). | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts ER calcium stores, causing ER stress, which might lead to increased expression of MANEAL as part of the cellular stress response. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine might lead to DNA demethylation and potentially activate the expression of genes involved in ER function and protein folding, including MANEAL. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences cell differentiation and might modulate MANEAL expression as part of its regulatory effects on protein processing and cell development. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises cAMP levels, potentially affecting MANEAL expression through cAMP-dependent signaling pathways involved in cellular stress and metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory and antioxidant properties, potentially influencing MANEAL expression as part of the cellular response to oxidative stress. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts ER-Golgi transport, potentially increasing ER stress and influencing the expression of proteins like MANEAL involved in glycoprotein processing. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As an HDAC inhibitor, Sodium butyrate might enhance the transcription of MANEAL by increasing histone acetylation and improving chromatin accessibility. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Beta-Estradiol can modulate gene expression and might influence MANEAL expression through estrogen receptor-mediated signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a glucocorticoid, could affect MANEAL expression related to stress responses and inflammation, potentially influencing protein processing mechanisms. | ||||||