Date published: 2026-4-1

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MAN2A2 Activators

MAN2A2 activators belong to a distinct chemical category of compounds recognized for their ability to modulate the activity of the MAN2A2 enzyme, which plays a crucial role in glycosylation processes within cells. MAN2A2, also known as α-mannosidase II, is an enzyme responsible for trimming and processing N-linked glycans on glycoproteins, a critical step in glycoprotein maturation. These activators are specifically designed to interact with MAN2A2 and influence its enzymatic function. At the molecular level, their mechanisms of action typically involve binding to specific regions of the MAN2A2 enzyme, potentially inducing conformational changes that affect its catalytic efficiency. By fine-tuning MAN2A2 activity, these compounds contribute to the complex orchestration of glycosylation, a fundamental cellular process with far-reaching implications for protein function and cell physiology.

The study of MAN2A2 activators is pivotal for advancing our understanding of glycoprotein processing and cellular glycosylation pathways. While the potential applications of these compounds may extend to various scientific and biomedical contexts, current research primarily centers on elucidating the precise molecular mechanisms by which MAN2A2 activators impact MAN2A2 function. This knowledge contributes to unraveling the intricacies of glycoprotein maturation, glycan structure, and their implications for cellular processes such as cell adhesion, signaling, and immune recognition. Ultimately, understanding MAN2A2 activators offers insights into the fine-tuned regulation of glycosylation, shedding light on the critical role of glycoproteins in cellular biology and providing a foundation for further exploration in the fields of biochemistry and cell biology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

An antibiotic known to inhibit N-linked glycosylation in the first step, causing ER stress.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Induces ER stress by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA).

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Disrupts protein transport from the ER to the Golgi apparatus.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$70.00
$215.00
26
(2)

Induces ER stress by interfering with glycosylation.

Monensin A

17090-79-8sc-362032
sc-362032A
5 mg
25 mg
$155.00
$525.00
(1)

Disrupts protein transport in the Golgi, which could influence glycoprotein maturation.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

Proteasome inhibitor which can cause accumulation of misfolded proteins in the ER.

Swainsonine

72741-87-8sc-201362
sc-201362C
sc-201362A
sc-201362D
sc-201362B
1 mg
2 mg
5 mg
10 mg
25 mg
$138.00
$251.00
$631.00
$815.00
$1832.00
6
(1)

Inhibitor of alpha-mannosidase, directly affecting glycoprotein processing.

4-Phenylbutyric acid

1821-12-1sc-232961
sc-232961A
sc-232961B
25 g
100 g
500 g
$53.00
$136.00
$418.00
10
(1)

Chemical chaperone that alleviates ER stress.

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
$114.00
$203.00
$354.00
$697.00
$1363.00
$5836.00
12
(1)

Inhibitor of ER-associated degradation, which can influence glycoprotein processing.

Celgosivir

121104-96-9sc-488385
sc-488385A
sc-488385B
5 mg
25 mg
100 mg
$525.00
$902.00
$2700.00
(0)

An iminosugar that inhibits glycosylation enzymes in the ER.