MAdCAM Inhibitors
MAdCAM inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule 1), a protein primarily involved in immune cell trafficking and adhesion. MAdCAM-1 is expressed on the endothelial cells of blood vessels in mucosal tissues and plays a crucial role in guiding lymphocytes, particularly T and B cells, to mucosal surfaces through interactions with integrins like α4β7 on immune cells. This interaction allows lymphocytes to home into specific tissues, contributing to immune surveillance and the maintenance of mucosal immune integrity. By inhibiting MAdCAM-1, researchers can block the adhesion of immune cells to the mucosal tissues, providing valuable insights into the mechanisms regulating immune cell trafficking, tissue-specific immune responses, and cellular communication within the immune system.
In research, MAdCAM inhibitors are instrumental in studying how immune cells migrate to mucosal tissues and how these processes are regulated by cell adhesion molecules. Blocking MAdCAM-1 activity allows scientists to explore the downstream effects on lymphocyte trafficking, adhesion dynamics, and immune cell activation. This inhibition provides a unique opportunity to investigate how the disruption of MAdCAM-1-mediated adhesion impacts immune cell behavior, immune surveillance, and the organization of immune responses in mucosal tissues such as the gastrointestinal tract, respiratory system, and other mucosal surfaces. Additionally, MAdCAM inhibitors help researchers understand the broader role of adhesion molecules in controlling immune responses, tissue-specific homing of immune cells, and the overall coordination of immune system function. Through these studies, the use of MAdCAM inhibitors contributes to a deeper understanding of immune cell migration and the molecular mechanisms that regulate mucosal immunity and tissue-specific immune processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine offers thiol-containing antioxidant properties which can inhibit the oxidative stress-related activation of MAdCAM. The oxidative stress can induce the upregulation of adhesion molecules like MAdCAM; by providing antioxidative support, N-Acetylcysteine can inhibit the oxidative stress-mediated upregulation of MAdCAM. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit the NF-κB pathway, which is responsible for the transcription of many pro-inflammatory genes, including MAdCAM. By inhibiting NF-κB translocation to the nucleus, Curcumin can prevent the transcriptional activation of MAdCAM. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can inhibit the activation of NF-κB and subsequent inflammatory processes, which includes the functional expression of MAdCAM. Without the transcriptional activity of NF-κB, the protein levels of MAdCAM are reduced, leading to functional inhibition. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin has been shown to inhibit protein kinase C, which plays a role in the activation of NF-κB. By inhibiting this kinase, Apigenin can prevent the activation of NF-κB and the subsequent upregulation of MAdCAM. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to inhibit the JNK signaling pathway, which can be involved in the expression of MAdCAM. By inhibiting JNK, Quercetin can reduce the functional activation of MAdCAM. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate can inhibit the expression of vascular adhesion molecules by inhibiting NF-κB. This inhibition prevents the functional expression of MAdCAM. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
Myricetin can inhibit the phosphorylation of key signaling proteins involved in the NF-κB pathway, which in turn, can inhibit the functional expression of MAdCAM. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein inhibits the oxidative stress pathway and can also inhibit NF-κB, leading to decreased expression and functional activity of MAdCAM. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol can inhibit the PI3K/Akt pathway, which is involved in the transcriptional activation of several adhesion molecules, including MAdCAM. By inhibiting this pathway, Kaempferol can inhibit the functional activity of MAdCAM. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is known to inhibit the activation of NF-κB, which is a transcription factor that plays a critical role in the expression of MAdCAM. Inhibition of NF-κB by Luteolin can therefore inhibit the functional expression of MAdCAM. | ||||||