MAD2L1BP Inhibitors
MAD2L1BP inhibitors are a class of chemical compounds designed to target and interact with the MAD2L1BP protein. MAD2L1BP, also known as MAD2B or REV7, is a crucial player in cellular processes related to DNA repair and maintenance of genomic stability. Its primary function lies in facilitating DNA damage response pathways and promoting error-free repair mechanisms. The development of MAD2L1BP inhibitors stems from the desire to gain a deeper understanding of the protein's role in these processes and potentially harness its regulatory functions for various scientific applications.
These inhibitors are characterized by their ability to bind specifically to MAD2L1BP, modulating its activity or interactions with other proteins involved in DNA repair. By targeting MAD2L1BP, researchers aim to dissect the intricate mechanisms by which this protein coordinates DNA damage responses and cell cycle control. Such insights can shed light on the fundamental processes that govern genome integrity and may have implications in understanding diseases associated with DNA damage. The development and utilization of MAD2L1BP inhibitors in experimental settings provide valuable tools for dissecting the molecular pathways involved in DNA repair and genomic stability, ultimately advancing our knowledge in this critical area of biological research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Binds to beta-tubulin and stabilizes microtubules, preventing the mitotic spindle from functioning properly which can indirectly inhibit MAD2L1BP by disrupting its role in the spindle assembly checkpoint. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds tubulin and inhibits its polymerization, leading to mitotic arrest and interference with MAD2L1BP's role in checkpoint signaling by disrupting microtubule dynamics. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Interferes with microtubule assembly, thereby affecting the mitotic spindle and potentially inhibiting MAD2L1BP's interaction with the spindle assembly checkpoint. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Inhibits tubulin polymerization, thereby affecting microtubule function and possibly inhibiting MAD2L1BP's role in the spindle checkpoint. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
A kinesin Eg5 inhibitor that disrupts mitotic spindle formation, potentially disturbing MAD2L1BP activity in the spindle assembly checkpoint. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A protein kinase C inhibitor that can indirectly affect MAD2L1BP by altering signaling pathways that regulate cell cycle and mitosis. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Cyclin-dependent kinase inhibitor, affecting cell cycle progression and potentially influencing MAD2L1BP's function in cell cycle control. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
A cyclin-dependent kinase inhibitor that can alter cell cycle progression, thereby potentially affecting MAD2L1BP's function in checkpoint control. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
A specific inhibitor of kinesin Eg5 that can disrupt spindle formation, indirectly inhibiting MAD2L1BP's role in the spindle assembly checkpoint. | ||||||