MAD2L1BP Antibody (4-RE23): sc-134381

MAD2L1BP Antibody (4-RE23) is a mouse monoclonal IgG2a kappa light chain antibody that detects MAD2L1BP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MAD2L1BP antibody (4-RE23) is available as a non-conjugated format. MAD2L1BP, also known as CMT2, is a crucial 274 amino acid protein that plays a significant role in the cell cycle, particularly during mitosis. MAD2L1BP is primarily located in the nucleoplasm during early mitosis and transitions to the spindle during metaphase through anaphase, highlighting MAD2L1BP′s importance in ensuring proper chromosome segregation. As a key component of the spindle checkpoint, MAD2L1BP helps delay the onset of anaphase until all kinetochores are properly attached, thereby preventing errors in chromosome distribution that could lead to aneuploidy. MAD2L1BP interacts with MAD2, which is essential for silencing the spindle checkpoint and allowing mitosis to proceed smoothly. The gene encoding MAD2L1BP is located on human chromosome 6, which is notable for containing a substantial portion of the human genome, and MAD2L1BP is expressed in multiple alternatively spliced isoforms that may undergo phosphorylation by ATM or ATR in response to DNA damage, further underscoring MAD2L1BP′s role in maintaining genomic stability.

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MAD2L1BP Antibody (4-RE23) References:

1. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells.  |  Howell, BJ., et al. 2000. J Cell Biol. 150: 1233-50. PMID: 10995431
2. Identification of a MAD2-binding protein, CMT2, and its role in mitosis.  |  Habu, T., et al. 2002. EMBO J. 21: 6419-28. PMID: 12456649
3. Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.  |  Xia, G., et al. 2004. EMBO J. 23: 3133-43. PMID: 15257285
4. Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma.  |  Yun, MY., et al. 2007. Exp Mol Med. 39: 508-13. PMID: 17934339
5. p31comet blocks Mad2 activation through structural mimicry.  |  Yang, M., et al. 2007. Cell. 131: 744-55. PMID: 18022368
6. Checkpoint control: the journey continues.  |  Peters, JM. 2008. Curr Biol. 18: R170-2. PMID: 18302922
7. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.  |  Nagase, T., et al. 1995. DNA Res. 2: 37-43. PMID: 7788527

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAD2L1BP Antibody (4-RE23) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-MAD2L1BP Antibody (4-RE23) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAD2L1BP Antibody (4-RE23) Specifications

Alternate Product Name: MAD2L1BP

Product Clone Name: 4-RE23

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-275

Epitope Target: MAD2L1BP

Epitope Species: human

Product Reactivity/Detection: MAD2L1BP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for MAD2L1BP Antibody (4-RE23): N/A