LYCAT Inhibitors
LYCAT inhibitors belong to a specialized category of chemical compounds designed to target and modulate the activity of LYCAT, which stands for Lysocardiolipin Acyltransferase. LYCAT is a mitochondrial enzyme that plays a crucial role in the metabolism and regulation of cardiolipin, a unique phospholipid predominantly found in the inner mitochondrial membrane. Cardiolipin is essential for various mitochondrial processes, including electron transport chain function, membrane integrity, and the regulation of mitochondrial dynamics. LYCAT facilitates the conversion of lysocardiolipin, a precursor molecule, into mature cardiolipin by acylating it with fatty acids. Inhibitors of LYCAT are developed to interact with this specific enzyme, influencing its enzymatic activity, cardiolipin biosynthesis, or its roles in maintaining mitochondrial structure and function.
Structurally, LYCAT inhibitors are meticulously designed to engage specific regions or binding sites on the LYCAT enzyme. This interaction may disrupt the normal functioning of LYCAT, affecting its ability to convert lysocardiolipin into cardiolipin and impacting the composition and properties of the mitochondrial inner membrane. The mechanisms by which LYCAT inhibitors exert their effects can vary, but their primary objective is to serve as valuable tools for researchers investigating the roles of cardiolipin and LYCAT in mitochondrial physiology. Studying the biochemical and functional aspects of LYCAT and its modulation by inhibitors can contribute to a deeper understanding of mitochondrial bioenergetics, membrane dynamics, and the broader field of cellular metabolism. Ultimately, such research can offer insights into the intricate molecular mechanisms that govern mitochondrial function and their regulation through LYCAT inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
R-(+)-Etomoxir | 124083-20-1 | sc-208201A sc-208201 | 2 mg 5 mg | $245.00 $430.00 | ||
Etomoxir is a known inhibitor of mitochondrial fatty acid oxidation. By affecting this pathway, it could potentially influence the substrate availability for LYCAT, thereby indirectly impacting its function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits ATP synthase in mitochondria. By impacting mitochondrial function, it might influence the need for cardiolipin remodeling and thus affect LYCAT activity indirectly. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
As an inhibitor of the mitochondrial respiratory chain, Antimycin A affects mitochondrial health. Disruptions in mitochondrial function might necessitate changes in cardiolipin remodeling, thereby influencing LYCAT indirectly. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP uncouples oxidative phosphorylation in mitochondria. By doing so, it can disturb mitochondrial health and might indirectly influence LYCAT activity and cardiolipin remodeling. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits mitochondrial complex I. This could potentially affect the overall health of the mitochondria and, in turn, influence the remodeling of cardiolipin by LYCAT. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
MitoQ, a mitochondrial-targeted antioxidant, affects mitochondrial oxidative stress. By modulating oxidative stress, it could potentially influence cardiolipin integrity and the role of LYCAT in its remodeling. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
DNP is an uncoupler of oxidative phosphorylation. By affecting mitochondrial ATP production, it might influence mitochondrial membrane dynamics and thus have implications for LYCAT function. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone is a PPARγ agonist. PPARγ plays roles in lipid metabolism, and its modulation might indirectly influence lipid remodeling enzymes such as LYCAT. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin is a potassium ionophore that disrupts mitochondrial membrane potential. Alterations in the mitochondrial membrane might influence cardiolipin dynamics and LYCAT function. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate is a PPARα agonist. By modulating lipid metabolism pathways, it might indirectly influence enzymes involved in lipid remodeling, including LYCAT. | ||||||