Date published: 2026-4-5

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LXR alpha Activators

Santa Cruz Biotechnology now offers a broad range of LXR alpha Activators for use in various applications. LXR alpha (Liver X Receptor alpha) is a nuclear receptor that plays a critical role in regulating genes involved in lipid metabolism, cholesterol homeostasis, and inflammation. LXR alpha Activators are essential tools in scientific research for understanding how this receptor modulates these vital biological processes. By activating LXR alpha, researchers can investigate the pathways that control lipid and cholesterol metabolism, providing insights into cellular mechanisms that maintain metabolic balance. These activators are used to explore the transcriptional regulation of genes by LXR alpha, offering a deeper understanding of the receptor's role in metabolic functions and systemic homeostasis. LXR alpha Activators are also employed in high-throughput screening assays to identify new modulators of LXR activity, facilitating the discovery of novel pathways and regulatory mechanisms. This research is crucial for advancing knowledge of metabolic regulation and its implications in cellular physiology and biochemical processes. By studying LXR alpha activation, scientists can gain valuable insights into the receptor's influence on lipid metabolism and its broader impact on biological systems. View detailed information on our available LXR alpha Activators by clicking on the product name.

Items 11 to 16 of 16 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Desmosterol

313-04-2sc-214871
sc-214871A
5 mg
10 mg
$94.00
$165.00
1
(1)

An intermediate in the cholesterol biosynthesis pathway; can act as a natural LXRα agonist.

Lithocholic acid

434-13-9sc-215262
sc-215262A
10 g
25 g
$100.00
$272.00
1
(1)

Secondary bile acid that has been reported to increase LXRα expression in certain contexts.

β-Sitosterol

83-46-5sc-204432
sc-204432A
10 g
25 g
$61.00
$217.00
5
(1)

Plant-derived sterols that may upregulate LXRα expression under specific conditions.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Found in cruciferous vegetables, it's shown potential in modulating LXRα expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

A natural polyphenol from turmeric; has shown potential to modulate LXRα activity and expression in some studies.

24(S)-Hydroxycholesterol

474-73-7sc-471350
sc-471350A
sc-471350B
1 mg
5 mg
10 mg
$97.00
$418.00
$774.00
1
(0)

24(S)-Hydroxycholesterol serves as a selective ligand for liver X receptor alpha (LXRα), facilitating unique conformational changes that promote receptor dimerization. This compound exhibits distinct interactions with the receptor's ligand-binding domain, influencing downstream signaling pathways related to lipid homeostasis. Its presence in cellular membranes can alter membrane fluidity, impacting protein interactions and cellular signaling dynamics, thereby playing a critical role in metabolic regulation.