LUZP1 Inhibitors
LUZP1 Inhibitors are a collection of chemical entities that interfere with the cytoskeletal interactions and functions of LUZP1, a protein associated with the cytoskeleton. For instance, hydroxyfasudil and Y-27632, both inhibitors of Rho-associated protein kinase (ROCK), disrupt actin dynamics by impeding the kinase's role in actin organization. This disturbance can reduce LUZP1's ability to bind to actin filaments, thus inhibiting its function. Similarly, blebbistatin and ML-7 target the actomyosin structure; blebbistatin hampers myosin II ATPase activity while ML-7 inhibits myosin light chain kinase (MLCK), both leading to altered actin filament organization and potentially diminishing LUZP1's interactions with the cytoskeleton. CK 636 and SMIFH2 work by inhibiting actin nucleation, the former by targeting the Arp2/3 complex and the latter by suppressing formin-mediated actin assembly, respectively, which could reduce the stabilization of actin filaments crucial for LUZP1's function.
Moreover, compounds such as Latrunculin A, Cytochalasin D, and Jasplakinolide specifically bind to actin monomers or filaments, either preventing polymerization or promoting filament aggregation, which could inhibit LUZP1's structural-dependent functions. Wiskostatin, an inhibitor of the actin-binding protein N-WASP, disrupts actin filament assembly, indirectly affecting LUZP1's role in the cytoskeleton. Additionally, although not directly targeting actin, colchicine and Taxol affect microtubules; colchicine inhibits their polymerization while Taxol stabilizes them. These alterations in microtubule dynamics could indirectly influence LUZP1's functional role within the broader cytoskeletal network, emphasizing the interconnected nature of the cytoskeletal components and their regulatory proteins. Collectively, these inhibitors exert their effects through diverse mechanisms, all converging on the functional diminishment of LUZP1 by perturbing the cytoskeletal structures and processes it is associated with.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is another well-known inhibitor of ROCK. By inhibiting ROCK, Y-27632 disrupts the downstream signaling that stabilizes actin filaments. As LUZP1 is associated with the actin cytoskeleton, this perturbation could lead to a reduction in LUZP1's ability to interact with actin structures, thereby inhibiting its function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is an inhibitor of non-muscle myosin II ATPase activity. Since myosin II works in conjunction with actin filaments and LUZP1 is associated with the cytoskeleton, inhibiting myosin II can lead to changes in actin filament organization and potentially diminish the function of LUZP1. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 inhibits formin-mediated actin assembly. As formins are crucial for the polymerization and stabilization of actin filaments, and given LUZP1's association with the cytoskeleton, inhibition by SMIFH2 could decrease the functional stability of actin filaments and thus diminish the role of LUZP1. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, leading to the disassembly of actin filaments. Disrupting actin dynamics in this way could inhibit the structure-dependent functions of LUZP1, as it is associated with the actin cytoskeleton. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D also binds to the barbed ends of actin filaments, blocking polymerization and elongation. This destabilization of the actin cytoskeleton would likely impair the structural functions of LUZP1, which is known to interact with these cytoskeletal elements. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which phosphorylates myosin light chains, a step necessary for myosin contractility within the actin cytoskeleton. By inhibiting MLCK, ML-7 could lead to diminished actomyosin interactions, potentially reducing the functional interactions of LUZP1 with the actin cytoskeleton. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is a specific inhibitor of the actin-binding protein N-WASP, which is involved in actin polymerization. Inhibiting N-WASP with wiskostatin could lead to disruptions in actin filament assembly and thus indirectly diminish the role of LUZP1 in the cytoskeleton. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can also induce their aggregation. By altering the normal dynamics of actin, it could negatively impact the function of actin-associated proteins like LUZP1, potentially inhibiting its normal interactions with the cytoskeleton. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization, leading to the disassembly of microtubules. While LUZP1 is more closely associated with actin, the overall disruption of the cytoskeletal network by colchicine could indirectly affect LUZP1's functional role within the cytoskeleton. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and prevents their disassembly. Although it is not an actin-targeting agent, the stabilization of microtubules can have far-reaching effects on the cytoskeletal dynamics, potentially influencing the functional role of LUZP1. | ||||||