LURAP1 Inhibitors
LURAP1 inhibitors consist of several chemical entities that decrease the functional activity of LURAP1 by targeting the actin cytoskeleton and related signaling processes. NSC 23766, as a Rac1 inhibitor, disables the interaction between Rac1 and its guanine nucleotide exchange factors (GEFs), ultimately leading to a less dynamic cytoskeleton where LURAP1's activity is dampened. Similarly, ML 141 and CK 666 target Cdc42 and the Arp2/3 complex, respectively, each reducing the capacity for actin filament assembly and branching, which is a crucial aspect of LURAP1's role in the cell. The ROCK inhibitor Y-27632 and the myosin II inhibitor Blebbistatin both operate further downstream in the cytoskeletal machinery, diminishing cytoskeletal tension and cell motility, which are processes where LURAP1 plays a part. The inhibition of N-WASP-Arp2/3 interaction by Wiskostatin and the disruption of formin-mediated actin assembly by SMIFH2 also contribute to decreased LURAP1 activity by altering actin network formation.
Moreover, the effects of actin polymerization inhibitors like Latrunculin A, Cytochalasin D, Swinholide A, and Jasplakinolide exhibit a direct impact on the integrity of the actin cytoskeleton, leading to an indirect but significant reduction in LURAP1 activity. Latrunculin A binds to monomeric G-actin, Cytochalasin D caps the growing ends of actin filaments, Swinholide A severs existing filaments, and Jasplakinolide stabilizes filaments, each creating an environment where the normal functions of LURAP1 are diminished. Additionally, LY 294002 disrupts the PI3K/Akt pathway, affecting the endocytic and membrane trafficking roles of LURAP1. Collectively, these inhibitors orchestrate a multi-front assault on the actin cytoskeleton and associated signaling pathways, leading to a comprehensive diminution of LURAP1's functional activity within the cell.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
A formin homology 2 domain inhibitor that disrupts actin nucleation and elongation. As LURAP1 is implicated in cytoskeletal regulation, SMIFH2's inhibition of formin-mediated actin assembly can lead to diminished activity of LURAP1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that blocks the PI3K/Akt pathway. LURAP1 is implicated in endocytosis and membrane trafficking, and LY 294002's inhibition of PI3K can lead to reduced endocytosis and downstream signaling events, consequently diminishing LURAP1 activity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
A Cdc42 inhibitor that impedes the GTPase activity of Cdc42, a protein involved in actin filament assembly. Since LURAP1 is associated with actin cytoskeleton regulation, ML 141 indirectly reduces the functional activity of LURAP1 by disrupting actin polymerization. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
An Arp2/3 complex inhibitor that directly inhibits actin polymerization. LURAP1 is thought to have a role in actin dynamics; therefore, CK 666 can indirectly diminish LURAP1's function by stabilizing existing actin filaments and preventing new branch formation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that decreases phosphorylation of myosin light chain (MLC), leading to lower actin stress fiber formation. LURAP1's involvement in actin cytoskeleton reorganization suggests that Y-27632 indirectly diminishes the role of LURAP1 by reducing cytoskeletal tension. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
A myosin II inhibitor that blocks myosin's ATPase activity, leading to decreased muscle contraction and inhibition of cell migration. LURAP1's interaction with the actin cytoskeleton could be affected by blebbistatin, which diminishes LURAP1's role in cell motility. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
An inhibitor of the N-WASP-Arp2/3 interaction, which is essential for actin polymerization. By inhibiting this interaction, wiskostatin indirectly reduces LURAP1's function in actin filament branching and network formation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
An actin polymerization inhibitor that binds to monomeric G-actin, preventing its polymerization. This action indirectly leads to the diminished activity of LURAP1 by disrupting the actin cytoskeleton and related cellular processes in which LURAP1 is involved. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An inhibitor of actin polymerization that binds to the barbed ends of actin filaments, blocking elongation. Cytochalasin D's impact on actin dynamics indirectly leads to the diminished activity of LURAP1 since it relies on actin structures for its function. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
A dimeric actin filament severing and capping compound that can disassemble actin filaments. By disrupting the actin cytoskeleton, swinholide A indirectly diminishes the functional activity of LURAP1 in processes dependent on intact actin filaments. | ||||||