ML 141 CAS: 71203-35-5
MF: C22H21N3O3S
MW: 407.49
ML 141 is a potent Cdc42 GTPase inhibitor.

ML 141 (CAS 71203-35-5)

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Alternate Names: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
Application ML 141 is a potent Cdc42 GTPase inhibitor
CAS 등록번호: 71203-35-5
순도: ≥98%
분자량: 407.49
분자식: C22H21N3O3S
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

ML 141 is a selective, potent and reversible non-competitive inhibitor Cdc42, a Rho family GTPase member.


References

1. Surviladze, Z. et al. 2010. Probe Reports NIH. PMID: 21433396
2. Hong, L. et al. 2013. J. Biol. Chem. PMID: 23382385

Physical State :
Solid
용해도 :
Soluble in DMSO (100 mM), and ethanol (5 mM).
저장 :
Store at 4° C
녹는점 :
185-187° C
비등점 :
622.93° C at 760 mmHg (Predicted)
밀도 :
1.31 g/cm3 (Predicted)
굴절률 :
n20D 1.65 (Predicted)
IC50 :
Rho family GTPase cdc42: IC50 = 200 nM; Trypanosoma cruzi Replication: EC5050 = 2829 nM; Ras-related protein Rab-2: EC5050 = 704 nM; Cell division cycle 42: EC5050 = 3198 nM (human)
pK Values :
pKa: 10.39 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
2950007
MDL Number :
MFCD05987165
SMILES :
O=S(=O)(c1ccc(cc1)N4/N=C(/c2ccccc2)CC4c3ccc(OC)cc3)N

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ML 141 (CAS 71203-35-5)  논문정보

다른 사용자의 ML 141 (CAS 71203-35-5)사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 5 of {3} total

PMID: # 29934528  Khanna, P. et al. 2018. Sci Rep. 8: 9511.

PMID: # 28383550  Wassermann-Dozorets, R. et al. 2017. Cell Death Dis. 8: e2733.

PMID: # 28122282  Chien, WW. et al. 2017. Leuk. Res. 55: 41-48.

PMID: # 26902610  Paul, CD.|Shea, DJ.|Mahoney, MR.|Chai, A.|Laney, V.|Hung, WC.|Konstantopoulos, K.| et al. 2016. FASEB J. 30: 2161-70.

PMID: # 26943325  Li, Z. et al. 2016. Cell Death Differ.

Citations 1 to 5 of {3} total
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