Molecular structure of (S)-(−)-Blebbistatin, CAS Number: 856925-71-8
(S)-(−)-Blebbistatin (CAS 856925-71-8)
Alternate Names:
1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one; (−)-Blebbistatin
Application:
(S)-(−)-Blebbistatin is an inhibitor of myosin II
CAS Number:
856925-71-8
Purity:
≥98%
Molecular Weight:
292.34
Molecular Formula:
C18H16N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-(−)-Blebbistatin is a selective inhibitor of myosin II (MYH2). It also inhibits contraction of the cleavage furrow without disrupting of mitosis or the contractile ring assembly. (S)-(−)-Blebbistatin exhibits rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells. (S)-(−)-Blebbistatin, discovered in 2004, is an inhibitor of myosin II, a vital motor protein involved in muscle contraction. Recognized for its ability to impede myosin II-mediated cell contractility in vitro, this small molecule has emerged as a valuable asset in investigating the intricate biochemistry and physiology of muscle contraction. Its application extends to in vitro studies, where it has been employed to delve into the mechanisms governing muscle contraction and its regulation in various cell culture systems.
(S)-(−)-Blebbistatin (CAS 856925-71-8) References
- Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. | Straight, AF., et al. 2003. Science. 299: 1743-7. PMID: 12637748
- Specificity of blebbistatin, an inhibitor of myosin II. | Limouze, J., et al. 2004. J Muscle Res Cell Motil. 25: 337-41. PMID: 15548862
- Myosin IIA is required for cytolytic granule exocytosis in human NK cells. | Andzelm, MM., et al. 2007. J Exp Med. 204: 2285-91. PMID: 17875677
- The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. | Lucas-Lopez, C., et al. 2008. Org Biomol Chem. 6: 2076-84. PMID: 18528569
- In vitro and in vivo relaxation of corpus cavernosum smooth muscle by the selective myosin II inhibitor, blebbistatin. | Zhang, XH., et al. 2009. J Sex Med. 6: 2661-71. PMID: 19686429
- Label-free detection of cell-contractile activity with lipid nanotubes. | Sugihara, K., et al. 2013. Integr Biol (Camb). 5: 423-30. PMID: 23212045
- The effect of kinase, actin, myosin and dynamin inhibitors on host cell egress by Toxoplasma gondii. | Caldas, LA., et al. 2013. Parasitol Int. 62: 475-82. PMID: 23624149
- Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells. | Pelekanos, RA., et al. 2014. BMC Cell Biol. 15: 15. PMID: 24885150
- The effects of actomyosin disruptors on the mechanical integrity of the avian crystalline lens. | Won, GJ., et al. 2015. Mol Vis. 21: 98-109. PMID: 25684975
- Intracellular sodium elevation reprograms cardiac metabolism. | Aksentijević, D., et al. 2020. Nat Commun. 11: 4337. PMID: 32859897
- Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration. | Kim, H., et al. 2022. Sci Rep. 12: 11449. PMID: 35794197
Inhibitor of:
α T-catenin, αPIX, β-centractin, β-Dystrobrevin, 2510006D16Rik, 3110003A17Rik, 3830431G21Rik, 4.1R, 4921517D21Rik, 4930403N07Rik, 4930404N11Rik, 4931429I11Rik, 4932411E22Rik, 4932418E24Rik, 6230427J02Rik, 6430531B16Rik, 6720456B07Rik, 7420426K07Rik, ABLIM1, ABLIM2, Abp β, ACTBL1, ACTL10, ACTL7A, ACTL8, ACTR10, AFAP-1L2, ALX1, AP-4ε, ARHGEF15, ARMCX1, ArpM1, Astrotactin, ATPase, AVL9, BAIAP2L1, BPAG1, BR-cadherin, C11orf47, C11orf56, C17orf74, C20orf134, CACHD1, cadherin-20, cadherin-24, cadherin-26, Calponin 1, CapZ-α, CapZ-α2, CARMIL, CCDC158, CCDC32, CCDC38, CCDC60_Ccdc60, CCDC78, CCDC87, CDH20, CERCAM, CGREF1, CMYA5, CNTD2, COBLL1, Cordon-bleu, Coronin 2B, CRP2, Crumbs, CTU1, Cypher, Cytospin-A, DCHS1, DIAPH3, DNALI1, DSC1, EG666713, EHBP1L1, ephrin-A1, FAM160A2, FAM161A, FAM184B, FAM65B, FBF1, FBLIM1, FCHSD1, FHL-4, Filamin 3, FLJ38973_1700066M21Rik, FMNL3, FND3C2, Fndc3c1, Frabin, FRMD7, Gas2L2, Gas8, Gm281, Gm996, GPBP1L1, Harmonin, HIP-55, HSPC300, Integrin αE, IPP, ITFG1, KBTBD7, KIAA1407, Kindlin-3, KLHDC7B, KLHDC9, KRTAP10-7, LAD1, Lamellipodin, Laminin β-2, Leiomodin 3, LGN, Liprin β1, LOC100041324, LOC441005, LOC635396, LOC728809, LRCH1, LRCH2, LRRC16B, LRRC9, LRRN2, LRRN4CL, LSP1, LURAP1, LUZP2, MAGI-1, melusin, MICAL, MICAL1, MIRAB13, MKX, MNS1, MORN1, Muscle Actin, Muskelin, MYH14, MYH2, MYH8, MYL10, MYL2, MYL4, MYL6, MYL7, Myoferlin, myomesin-2, Myosin, Myosin Id, Myosin VIIa, Myosin XVI, Myosin XVIIIb, Myosin-13, Myosin-XVA, Myozenin 3, MYPT2, N-twist, NBEAL2, Nebulin, NEPH1, neuroligin X, Neuroplastin, NYD-SP29, OBSL1, Odf3, OGFRL1, palladin, PARD3A, PCDHA13, PCDHA7, PCDHAC, PDCL3, PHACTR4, plakophilin 2, plakophilin 4, PLEKHA7, PLEKHH3, PLET1, POF1B, Profilin-4, PRR12, Rab 16, Rab L4, Rab11-FIP2, RAB6IP1, RGNEF, Rho F, Rho T2, RHOBTB3, rhophilin-2, RICS, RIM-BP2, RNF4, Rootletin, Sec3, SEMA4C, SEMA6D, Septin 10, Septin 6, shootin1, SHROOM4, SMPX, SPACA1, SPARCL1_Sc1, SPECC1, spectrin β I, spectrin β IV, Spir-1, STAC3, STARS, SUCO, Supervillin, SYAP1, Synaptopodin, Syne-1, Syne-3, Syne-4, syntenin-2, T-Plastin, T1-cadherin, TANC, TBC1D12, TBCEL, Tektin 1, Tektin 2, THSD3, TM4-B, Tropomyosin, Tropomyosin β, Troponin I-SS, vinculin, WIRE, Xinα, and ZNF609.Activator of:
β-parvin, β-taxilin, 1110007A13Rik, 6430537H07Rik, ABHD3, ABHD9, Abp1, ACTBL1, ACTG1, ACTG2, ACTL10, Ajuba, ALG-2, ARA55, ARFRP1, ArgBP2, ARHGAP15, ARHGAP27_Arhgap27, ARHGAP30, ARHGAP36, ARHGAP40, ARHGAP42, ARL13B, Arp3C, ARPC5L, ATP9B, atrophin-2, BC024814, BIN3, C19orf69, C20orf134, C4orf47, C5orf43, C5orf58, C6orf81, C7orf72, C8orf59, CapZ-α2, CapZ-β, CCDC116, CECR5, CERCAM, CLCP1, COL13A, COL1A1, COL6A, Coronin 6, Dermatopontin, DOCK 6, DYSFIP1, ECT2L, EGFL4, ENSMUSG00000071517, Eps8, ESPNL, EVL, FAM190A, FAM21A, FAM38B, FARP1, FCHSD2, FGD1, FGF-11, Fibulin-7, FMNL1, FNBP4, Fndc3c1, FRMD3, Gm597, Gm732, Gm996, GPR128, GRF-1, GRO1, IGLON5, IQGAP3, KIF3B, Klp3, KRAP, Las17, Leiomodin 1, Leiomodin1, Lfc, Liprin β2, LPAAT-ε, LRRC66, MACF1, MAGE-A9, MOBP, MPP2, MRCKα, MrgA4, MRTF-B, MSE55, Myosin IIIb, Myosin IXa, Myosin Vc, Myosin-XIX, MYPT3, NHS, OR1K1, OR1L3, PACSIN1, PAP-2c, PCTAIRE-1, Pinin, PLEKHG6, plexin-A2, PLP-B, PLP-Cβ, POF1B, Profilin-3, Ran BP-4, Rho GAP p190, Rho GDIγ, Rhox4a, SCFD2, SEC14L2, SEMA3F, Sept14, Septin 12, Septin 8, Slac2-a, SMTNL1, SPARCL1_Sc1, SPATA13, SPCS2, SRGAP1, SVEP1, SYDE1, SYDE2, Syne-1, Syne-2, Tmsbl1, Tns, TOCA-1, transgelin-2, tropomodulin, Tropomyosin α, TSPAN2, V-ATPase E, Vac17p, WDR47, WIP, YKL-39, ZDHHC24, and ZNRF4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(−)-Blebbistatin, 1 mg | sc-204253 | 1 mg | $72.00 | |||
(S)-(−)-Blebbistatin, 5 mg | sc-204253A | 5 mg | $265.00 | |||
(S)-(−)-Blebbistatin, 10 mg | sc-204253B | 10 mg | $495.00 | |||
(S)-(−)-Blebbistatin, 25 mg | sc-204253C | 25 mg | $968.00 |