LSm12 Inhibitors
LSm12 inhibitors are a class of chemical compounds that target a specific protein known as LSm12, which plays a crucial role in various cellular processes, particularly in the regulation of mRNA decay and processing. LSm12, short for Like-Sm 12, is a component of the LSm (Like-Sm) protein complex, which is involved in the degradation and maturation of RNA molecules within the cell. This complex is conserved across eukaryotic organisms and is essential for maintaining proper RNA stability and gene expression. LSm12 inhibitors are designed to interfere with the function of LSm12, leading to disruptions in RNA metabolism and potentially impacting gene expression patterns.
LSm12 inhibitors typically involves binding to the LSm12 protein, either directly or indirectly, to disrupt its normal interactions with other components of the LSm complex. By doing so, these inhibitors can hinder the assembly and function of the LSm complex, thereby impairing its ability to degrade or process mRNA molecules efficiently. This interference with RNA regulation can have downstream effects on cellular processes such as mRNA decay, translation, and splicing. Researchers have been exploring LSm12 inhibitors as valuable tools in molecular biology and cellular studies to better understand the intricate mechanisms of RNA metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is a diterpene triepoxide that inhibits transcriptional activity by affecting RNA polymerase II, which can indirectly reduce the function of proteins involved in RNA processing such as LSm12. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and disrupts DNA-dependent RNA polymerase activities, possibly reducing LSm12-related mRNA processing. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA polymerase II transcription elongation, which can indirectly affect proteins like LSm12 that are involved in mRNA processing. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II and, by extension, can affect RNA splicing and turnover, processes in which LSm12 proteins may play a role. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits nuclear export of RNA, which could impact the functionality of LSm12 in RNA processing. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $240.00 | ||
CX-5461 selectively inhibits RNA polymerase I, which may indirectly impact LSm12 function by altering ribosomal RNA biogenesis and possibly affecting mRNA splicing. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol is a cyclin-dependent kinase inhibitor that affects transcription and could indirectly influence LSm12 activity in mRNA processing. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Cordycepin is an adenosine analog that disrupts RNA synthesis and may indirectly influence the role of LSm12 in RNA processing. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
BMH-21 binds to RNA polymerase I and inhibits ribosomal RNA synthesis, which could indirectly affect LSm12 activity. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Pladienolide B targets the spliceosome, thereby potentially influencing the activity of LSm12 by affecting splicing. | ||||||