LRRIQ1 Inhibitors
Chemical inhibitors of Leucine-Rich Repeat And IQ Motif Containing 1 (LRRIQ1) impede the proper functioning of this protein by targeting various cellular mechanisms essential for ciliogenesis, the process by which cilia are formed. Alsterpaullone, Roscovitine, Indirubin-3'-monoxime, Nu 6140, and Purvalanol A share a common target in their inhibition strategy: cyclin-dependent kinases (CDKs), which are pivotal in cell cycle regulation. Alsterpaullone's inhibition of CDKs can lead to cell cycle disruptions, thereby impairing the formation and maintenance of cilia and negatively affecting LRRIQ1 function. Similarly, Roscovitine's selective inhibition of CDKs can hinder the cell cycle-dependent processes that are crucial for ciliogenesis. Indirubin-3'-monoxime extends its impact by also inhibiting GSK-3β, a kinase involved in microtubule dynamics, which are vital to ciliary structure and function. Nu 6140's potent inhibition of CDK2 further underscores the pivotal role of cell cycle control in the regulation of ciliary processes, while Purvalanol A's effectiveness against CDKs underscores the importance of these kinases in maintaining the cellular environment conducive for LRRIQ1's role in cilia.
In parallel, ZM447439 and S-Trityl-L-cysteine target other essential components of cell division and ciliogenesis, further illustrating the multifaceted nature of LRRIQ1 inhibition. ZM447439 inhibits Aurora kinases, which are critical for chromosome alignment and segregation during mitosis, processes that are coordinated with the formation of cilia. Disruption of this coordination can affect ciliary assembly, thus inhibiting LRRIQ1. S-Trityl-L-cysteine's inhibition of the mitotic kinesin Eg5, necessary for spindle formation, can lead to defective cell division and, consequently, ciliogenesis. Nocodazole and Colchicine exert their inhibitory effects by directly disrupting microtubules, which are the structural components of cilia. Nocodazole achieves this by interfering with microtubule polymerization, while Colchicine binds to tubulin, preventing its polymerization and thus affecting ciliary formation and stability. Paclitaxel, conversely, stabilizes microtubules excessively, which can disrupt normal microtubule dynamics necessary for ciliary function. Lastly, Marimastat inhibits matrix metalloproteinases that remodel the extracellular matrix, a process that can influence the extracellular environment necessary for ciliogenesis and, by extension, the function of LRRIQ1. These chemical inhibitors, through their distinct mechanisms, converge on the critical pathways that govern the proper formation and function of cilia, where LRRIQ1 plays an integral role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone inhibits cyclin-dependent kinases (CDKs). Since LRRIQ1 has been shown to play a role in cilia function and structure, and CDKs are involved in cell cycle regulation which is essential for ciliogenesis, inhibition of CDKs can disrupt the cell cycle and consequently, the proper assembly or maintenance of cilia, leading to functional inhibition of LRRIQ1. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor. Aurora kinases are essential for proper spindle assembly and chromosome segregation during mitosis. As LRRIQ1 is implicated in cilia formation and maintenance, which is coordinated with cell cycle progression, inhibiting Aurora kinases can disrupt proper ciliogenesis and therefore inhibit the function of LRRIQ1. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine selectively inhibits CDKs, which are involved in the regulation of the cell cycle. Disruption of cell cycle control can impair ciliogenesis, a process in which LRRIQ1 plays a part. Therefore, roscovitine can inhibit the function of LRRIQ1 by impeding the cell cycle-dependent processes required for cilia formation. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a specific inhibitor of the mitotic kinesin Eg5. As LRRIQ1 is involved in cilia dynamics and Eg5 is critical for mitotic spindle formation, inhibition of Eg5 can lead to defective cell division and consequently affect ciliogenesis, thereby inhibiting LRRIQ1 function. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
Indirubin-3'-monoxime is known to inhibit CDKs and GSK-3β, which are involved in cell cycle regulation and microtubule dynamics. Since cilia formation and maintenance, processes associated with LRRIQ1, are closely tied to microtubule organization, this inhibitor can disrupt cilia function and thus inhibit LRRIQ1. | ||||||
NU 6140 | 444723-13-1 | sc-202531 | 5 mg | $147.00 | 1 | |
Nu 6140 is a potent CDK2 inhibitor, which affects cell cycle progression. By inhibiting CDK2, Nu 6140 can disrupt the cilia formation that relies on precise cell cycle control, leading to inhibition of LRRIQ1, which is implicated in the cilia structure and function. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
Marimastat is a broad-spectrum matrix metalloproteinase (MMP) inhibitor. MMPs are involved in extracellular matrix remodeling, which is important for cilia biogenesis and function. Inhibiting MMPs can affect the extracellular environment necessary for proper ciliogenesis, thus inhibiting LRRIQ1 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. Since LRRIQ1 is associated with cilia, which are composed of microtubules, nocodazole can inhibit cilia formation and function, effectively inhibiting the function of LRRIQ1. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent inhibitor of CDKs. By inhibiting CDKs, Purvalanol A can interfere with cell cycle progression and therefore ciliogenesis, leading to the inhibition of LRRIQ1, which has a role in cilia structure and function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can disrupt normal microtubule dynamics. This disruption can inhibit cilia function and thus inhibit LRRIQ1, which is involved in ciliary dynamics. | ||||||