LRRCC1 Activators

LRRCC1, or Leucine-Rich Repeat and Coiled-Coil Domain Containing 1, is a protein encoded by the gene LRRCC1 in humans. While the complete functional spectrum of LRRCC1 is not fully elucidated, proteins containing leucine-rich repeat (LRR) domains are typically involved in protein-protein interactions and have been implicated in a variety of cellular functions, including signal transduction, cell adhesion, DNA repair, and the regulation of gene expression.

The LRR domain is characterized by a series of tandem repeats, usually 20–29 amino acid residues in length, that form a horseshoe-shaped structure with a parallel β-sheet on the concave side and helical elements on the convex side. This conformation facilitates interactions with a diverse array of protein partners. The coiled-coil domain, on the other hand, is known to mediate protein dimerization and oligomerization, suggesting that LRRCC1 may participate in forming protein complexes.Given the structure of LRRCC1, it is plausible that this protein could function as a scaffold, bringing together multiple proteins to form signaling complexes. Such complexes could be vital for the transduction of signals from the cell surface to the interior, influencing cellular responses to environmental cues. Furthermore, the coiled-coil domain of LRRCC1 might be involved in maintaining the structural integrity of these complexes or mediating interactions with cytoskeletal elements, thus potentially influencing cell shape and motility.