LRP1 Activators
Common LRP1 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Dexamethasone CAS 50-02-2, Ob (hBA-147) CAS 177404-21-6 and PMA CAS 16561-29-8.
The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor and cell signaling molecule found in various tissues. It plays roles in lipid metabolism, cellular uptake of various molecules, and modulation of intracellular signaling pathways. LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Activators are a class of chemical compounds that modulate the activity of the LRP1 receptor. LRP1 is a large cell surface receptor found in various tissues, including the liver, brain, and vasculature. It plays a crucial role in diverse cellular processes such as lipid metabolism, cellular uptake of lipoproteins, and clearance of extracellular molecules. Activation of LRP1 can impact these processes and influence cellular homeostasis.
LRP1 is known to interact with numerous ligands, including apolipoprotein E (ApoE), tissue-type plasminogen activator (tPA), and matrix metalloproteinases (MMPs). Activation of LRP1 can lead to increased internalization and degradation of these ligands, affecting cellular functions. Additionally, LRP1 has been implicated in several diseases, including Alzheimer's disease, atherosclerosis, and cancer, making it a significant target for research. LRP1 Activators are valuable tools in studying the functions and regulation of this receptor, allowing scientists to unravel its complex roles in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences cell differentiation and might modulate LRP1 expression in certain cell types. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Can induce inflammatory responses, potentially upregulating LRP1 expression in immune-related cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid might modulate lipid metabolism and inflammatory pathways, potentially influencing LRP1 expression. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
This adipokine can modulate lipid metabolism and inflammatory pathways, potentially influencing LRP1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Might modulate various cellular responses, potentially influencing LRP1 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Can modulate cellular differentiation and lipid metabolism, potentially affecting LRP1 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, it might influence LRP1 expression in certain contexts. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPARγ agonists that modulate lipid metabolism, potentially influencing LRP1 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Hormonal influence might modulate LRP1 expression, especially in lipid metabolism-related tissues. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
By reducing cholesterol levels, statins might modulate LRP1 expression and function. | ||||||