LOC729464 Inhibitors
Staurosporine is a potent kinase inhibitor with a broad spectrum of targets, making it capable of disrupting multiple signaling pathways that may be essential for the activity of LOC729464. U0126 specifically inhibits the MEK1/2, which are upstream of ERK, a pathway crucial for cell cycle progression and differentiation. Similarly, LY294002 targets PI3K and can therefore impede AKT signaling, influencing processes where LOC729464 might be implicated PP2's inhibition of Src family tyrosine kinases can lead to alterations in cell growth and differentiation, while Thapsigargin can elevate cytosolic calcium levels and affect calcium-dependent proteins. PD173074's blockade of FGFR can influence cell growth and angiogenesis, which are vital for tissue maintenance and repair. SP600125 disrupts JNK signaling, affecting cellular responses to stress and apoptosis.
The IκB kinase inhibitor blocks the activation of NF-κB, a transcription factor that regulates genes involved in inflammation and immune response. Bortezomib impedes the proteasome's ability to degrade proteins, affecting protein levels and turnover. 2-Deoxy-D-glucose hampers glycolysis, which is fundamental for energy production in cells. Sorafenib's inhibition of RAF kinase, as well as VEGFR and PDGFR, can interfere with cell proliferation and the development of new blood vessels. ZM-447439 targets Aurora kinases involved in cell division, potentially impacting proteins that are crucial for mitotic processes.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A non-selective protein kinase inhibitor that can inhibit a wide range of kinases, potentially altering signaling pathways that the protein is involved in. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An inhibitor of MEK1/2, which can prevent the activation of the ERK pathway, a common route for protein regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
An inhibitor of PI3K, which can hinder downstream AKT signaling, impacting processes such as cell proliferation and survival where the protein may play a role. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases, which can affect cell adhesion, growth, and differentiation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A SERCA pump inhibitor that can elevate cytosolic calcium concentration, affecting calcium-dependent proteins. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
An FGFR inhibitor that can block fibroblast growth factor signaling, which can impact cell growth and angiogenesis. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which can disrupt stress signaling pathways and apoptosis that the protein may be involved in. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $223.00 $942.00 | 2 | |
An inhibitor of IκB kinase that can prevent NF-κB activation, potentially affecting gene expression and cellular responses to inflammation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can affect protein degradation pathways, potentially influencing protein levels and function. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glycolysis inhibitor that can impair energy metabolism, impacting cellular processes the protein may be associated with. | ||||||