LOC728261 Inhibitors
Compounds like LY294002 and wortmannin can impede the PI3K/Akt signaling pathway, which is critical for cell survival and metabolism. By doing so, these inhibitors may indirectly affect proteins that are regulated by or dependent on this pathway. Similarly, U0126, PD98059, and SB203580 are designed to target kinases within the MAPK/ERK and p38 MAP kinase pathways, respectively. These pathways are integral to cell growth, differentiation, and the body's response to stress and inflammation.
Inhibitors like rapamycin that target mTOR signaling, on the other hand, can impinge upon cellular processes related to growth and metabolism. Agents such as SP600125, which inhibits JNK, may affect apoptosis and the immune system by modulating the activity of proteins involved in these processes. NF449, which inhibits the Gs-alpha subunit, can alter cyclic AMP-dependent signaling, and BAPTA-AM, by chelating intracellular calcium, can affect various calcium-dependent processes. Thapsigargin's role in disrupting calcium homeostasis through SERCA inhibition could influence numerous calcium-dependent signaling pathways. Lastly, 2-Deoxy-D-glucose, by inhibiting glycolysis, can alter cellular energy metabolism, potentially affecting proteins that rely on or regulate metabolic pathways.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Inhibits protein kinases, possibly affecting signaling pathways related to cell cycle regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibitor of PI3k/Akt signaling pathway, altering cell survival mechanisms. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Targets MEK1/2 in the MAPK/ERK pathway, potentially affecting cell proliferation and apoptosis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAP kinase, possibly impacting inflammatory response and stress-induced pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR signaling, possibly affecting cell growth and metabolism. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK in the MAPK pathway, potentially altering cell division and differentiation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, potentially affecting apoptosis and immune response. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
Inhibits Gs-alpha protein, possibly affecting cyclic AMP pathways. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Chelates intracellular calcium, potentially affecting calcium-dependent signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits sarcoplasmic/endoplasmic reticulum Ca2+ ATPases, affecting calcium homeostasis. | ||||||