LOC728181 Inhibitors
LOC728181 inhibitors comprise a spectrum of compounds that influence various cellular signaling pathways, potentially leading to the inhibition of LOC728181. Rapamycin is well-recognized for its inhibition of mTORC1, a master regulator of cell growth and proliferation. If LOC728181 is a protein that functions downstream of mTORC1, its activity would be reduced by rapamycin, which suppresses mTORC1's downstream signaling effects. Wortmannin and LY294002 both target PI3K, a kinase that is crucial for the activation of AKT. In scenarios where LOC728181 operates downstream of AKT, the inhibition of PI3K and the consequent reduction in AKT activation would lead to a decrease in LOC728181 activity.
Triciribine and Perifosine are inhibitors of AKT. By directly preventing the phosphorylation and activation of AKT, they would reduce the functional activity of LOC728181 if it is AKT-dependent. U0126 and PD0325901 are inhibitors of MEK, which is upstream of ERK in the MAPK pathway. If LOC728181 is regulated via the ERK pathway, inhibition of MEK by these compounds would result in decreased LOC728181 activity. Sorafenib is a RAF kinase inhibitor, which by inhibiting RAF, would also diminish downstream MEK/ERK signaling. LOC728181, if part of this pathway, would be inhibited as a result.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that suppresses mTORC1 activity. LOC728181, if involved in mTORC1 signaling, would have reduced activity due to the decreased downstream effects of mTORC1 inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that prevents the formation of PIP3, leading to reduced activation of AKT. If LOC728181 functions downstream of AKT, its activity would be diminished with PI3K inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor that similarly to Wortmannin, blocks the production of PIP3, and would thus indirectly inhibit LOC728181 if it is dependent on AKT signaling. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
An AKT inhibitor that directly prevents AKT phosphorylation. If LOC728181 activity is AKT-dependent, inhibition of AKT would lead to a decrease in LOC728181 activity. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
An alkylphospholipid that inhibits AKT activation. It would indirectly inhibit LOC728181 if the protein's function is mediated through AKT-dependent pathways. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
A RAF kinase inhibitor that also disrupts downstream MEK/ERK signaling. LOC728181 would be inhibited if it is part of the RAF/MEK/ERK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that impedes the JNK signaling pathway. LOC728181 would have reduced activity if JNK signaling is upstream of its functional pathway. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A Src family kinase inhibitor that prevents Src-mediated signaling. LOC728181's activity would be decreased if it is regulated by Src kinase signaling pathways. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
A selective mTOR kinase inhibitor that targets both mTORC1 and mTORC2, potentially inhibiting LOC728181 if it is involved in pathways regulated by mTOR. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
A dual mTORC1/mTORC2 inhibitor, which would lead to a comprehensive inhibition of mTOR signaling, indirectly affecting LOC728181 if it is mTOR-dependent. | ||||||