LOC728108 Inhibitors
Staurosporine and LY294002 are examples of kinase inhibitors that target broad and specific kinases, respectively. While Staurosporine is known for its wide-ranging inhibition of protein kinases, LY294002 specifically inhibits PI3K, thereby disrupting the PI3K/AKT pathway critical for cell survival and proliferation. Rapamycin is an mTOR inhibitor that affects cellular processes such as growth and autophagy, pathways that could be relevant to LOC728108 function. U0126 and PD98059 are both inhibitors of the MEK/ERK pathway, which is central to controlling cell differentiation and proliferation, indicating that LOC728108 might be modulated if it interacts with this pathway.
Proteasome inhibitors like Bortezomib and MG132 prevent the degradation of proteins that regulate cell cycle and apoptosis, suggesting that if LOC728108 is part of ubiquitin-proteasome pathway, its levels or activity could be affected. Thapsigargin disrupts calcium signaling by inhibiting SERCA, which could influence LOC728108 if it is calcium-dependent. SB203580's inhibition of p38 MAPK has implications for stress response and inflammation, potentially impacting LOC728108 if it is involved in these responses. Further, 2-Deoxy-D-glucose, by inhibiting glycolysis, affects ATP production, potentially influencing LOC728108 if it is energy-regulated. ZM-447439 disrupts cell division by inhibiting Aurora kinases, which could affect LOC728108 if it plays a role in mitosis. Lastly, Gefitinib, an EGFR inhibitor, could modulate LOC728108's function if it is part of the EGFR signaling pathway.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can inhibit a broad spectrum of protein kinases which might regulate LOC728108, if it is phosphorylation-dependent. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3Ks (phosphoinositide 3-kinases) that can block the PI3K/AKT pathway, which would affect LOC728108 if it is part of this signaling cascade. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which can suppress the mTOR signaling pathway, thereby potentially inhibiting LOC728108 if it is involved in cell growth or autophagy processes regulated by mTOR. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2 which would block the MAPK/ERK pathway, potentially affecting LOC728108 if it is involved in cell proliferation or differentiation pathways regulated by MAPK/ERK. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can prevent protein degradation, potentially increasing the levels of regulatory proteins that control LOC728108, if it is regulated by ubiquitination. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), which can disrupt calcium homeostasis, potentially influencing LOC728108 if it is calcium-dependent. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK1, which would block the activation of ERK, potentially affecting LOC728108 if it operates within the MAPK/ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that can block p38 MAPK signaling, potentially affecting LOC728108 if it is involved in response to stress or cytokine signaling. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can block the degradation of ubiquitinated proteins, potentially stabilizing factors that control LOC728108, if its activity is regulated by ubiquitination. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
An inhibitor of glycolysis that can reduce ATP production, potentially influencing LOC728108 if it is regulated by cellular energy levels. | ||||||