LOC728102 Inhibitors

Imatinib targets BCR-ABL tyrosine kinase and can inhibit signaling pathways that are crucial for cell proliferation and survival. This inhibition can alter the functions of associated proteins. Roscovitine, as a cyclin-dependent kinase inhibitor, can arrest the cell cycle, thus impacting proteins that regulate cell division. LY294002, by inhibiting PI3K, affects the PI3K/AKT signaling axis, leading to potential effects on proteins involved in cell growth and apoptosis. PD98059 and PD 184,352, both MEK inhibitors, impede the MAPK/ERK pathway, which is fundamental for cell differentiation and proliferation. This can lead to alterations in the function of proteins that are regulated by this pathway. Rapamycin, an mTOR inhibitor, affects the mTOR signaling pathway, which has broad effects on proteins involved in cell growth, metabolism, and autophagy.

U73122 can affect proteins regulated by calcium levels and diacylglycerol by inhibiting Phospholipase C, while SB203580 and SP600125 target the p38 MAPK and JNK pathways, respectively, impacting proteins involved in inflammatory responses and cellular stress. Bortezomib disrupts the ubiquitin-proteasome system, leading to the accumulation of proteins within the cell, which can affect numerous cellular functions. Gefitinib, by inhibiting EGFR tyrosine kinase, can affect downstream proteins involved in cell proliferation. Olaparib, as a PARP inhibitor, affects proteins involved in DNA repair mechanisms.