LOC653720 Inhibitors
Chemical inhibitors of LOC653720 operate through various mechanisms to impede the protein's function by targeting the cellular processes and pathways in which it is involved. Wortmannin and Dyngo-4a inhibit phosphoinositide 3-kinases (PI3K) and dynamin, respectively, both of which are pivotal in intracellular trafficking pathways. The inhibition of PI3K by Wortmannin disrupts the membrane trafficking route integral for LOC653720's function. Similarly, Dyngo-4a's targeted disruption of dynamin-mediated endocytosis can lead to a blockade in the endocytic pathways essential for LOC653720's role in the cell. MiTMAB and Dynasore, both dynamin inhibitors, further contribute to this blockade by preventing vesicle scission during endocytosis, which is a critical step in membrane trafficking where LOC653720 is presumed to be active.
On the other hand, chemicals like Paclitaxel, Nocodazole, Colchicine, and Vinblastine target the microtubule network within the cell. These inhibitors can lead to the stabilization or destabilization of microtubules, which are essential for the intracellular transport systems that LOC653720 depends on for its activity. By altering the dynamics of microtubules, these chemicals indirectly impede LOC653720's function. Cytochalasin D and Latrunculin A target the actin cytoskeleton, another structural component critical for cellular transport and motility. These inhibitors prevent the polymerization of actin, thereby potentially disrupting cellular processes that are dependent on the actin network, including those associated with LOC653720. Lastly, ML-7 and Blebbistatin act on myosin, a motor protein that moves along actin filaments, which is crucial for various cellular processes. By inhibiting myosin light chain kinase and myosin II activity, these chemicals can impair the vesicle transport processes and other motility-related functions that are necessary for LOC653720's role in the cell. Each of these chemicals, through their specific action on different cellular components, can contribute to the functional inhibition of LOC653720 by disrupting its associated cellular mechanisms.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibits PI3K, which is involved in the intracellular trafficking pathways where LOC653720 is functional. Inhibition of PI3K could lead to a disruption of membrane trafficking, indirectly inhibiting LOC653720's associated functions. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, which mediates vesicle scission during endocytosis, a process in which LOC653720 may play a role. Inhibition of dynamin function could thereby inhibit the endocytic functions associated with LOC653720. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $250.00 | ||
Acts as an inhibitor of dynamin, leading to the inhibition of clathrin-mediated endocytosis, a pathway necessary for the proper localization and function of LOC653720, thus indirectly inhibiting its function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and disrupts their dynamics, which could inhibit intracellular transport systems that are essential for the function of LOC653720, leading to its indirect inhibition. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule polymerization, which can impede the microtubule-dependent transport processes that LOC653720 requires for its function, thereby indirectly inhibiting LOC653720's activity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds tubulin and inhibits its polymerization into microtubules, which are crucial for vesicular transport mechanisms that involve LOC653720, thus indirectly inhibiting the functional role of LOC653720. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Binds tubulin, inhibiting microtubule formation, which is essential for intracellular transport and proper localization of LOC653720, leading to its functional inhibition. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Inhibits actin polymerization and can disrupt actin cytoskeleton dynamics, which can affect cellular processes involving LOC653720, leading to an indirect functional inhibition of LOC653720. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers and prevents their polymerization, which could inhibit cellular transport and motility processes where LOC653720 is functional, thus indirectly inhibiting its activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), which can affect cytoskeletal organization and intracellular trafficking, processes in which LOC653720 is potentially involved, leading to its indirect functional inhibition. | ||||||