LOC646864 Inhibitors
LOC646864 inhibitors encompass a range of compounds that target various components of the signaling pathways LOC646864 is involved in. LY294002 and Wortmannin, by inhibiting PI3K, lead to a cascade of deactivations within the PI3K/AKT/mTOR pathway, thereby indirectly inhibiting LOC646864. Their action ensures that the phosphorylation of AKT is decreased, which is a necessary step for mTOR activation, and subsequently, for the activation of LOC646864. Similarly, Rapamycin and its analogs like PP242, Torin 1, AZD8055, and KU-0063794, are mTOR inhibitors that act directly on the mTOR complex, either mTORC1 or both mTORC1 and mTORC2, to inhibit their kinase activity. This inhibition leads to a decrease in the phosphorylation of downstream targets, including LOC646864, thereby reducing its activity.
MK-2206 and Perifosine target AKT, a serine/threonine-specific protein kinase that plays a crucial role upstream of mTOR in the PI3K/AKT/mTOR signaling pathway. By inhibiting AKT, these compounds prevent the subsequent activation of mTOR and, consequently, the activation of LOC646864.BEZ235 (Dactolisib) is notable for its dual action, as it inhibits both PI3K and mTOR pathways. By blocking signaling at two critical points, BEZ235 has a more comprehensive inhibitory effect on the activation of LOC646864.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a selective inhibitor of PI3K, which is an upstream activator of the AKT/mTOR pathway. Inhibition of PI3K leads to decreased AKT phosphorylation and subsequent mTOR activity reduction. Since LOC646864 is postulated as a downstream effector of mTOR, LY294002 indirectly inhibits LOC646864 by impeding the PI3K/AKT/mTOR signaling cascade necessary for its activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that irreversibly binds to and inhibits the enzyme, leading to the suppression of the PI3K/AKT/mTOR pathway. By blocking this pathway, which is crucial for LOC646864 activity, Wortmannin indirectly reduces the functional activity of LOC646864 by preventing the requisite upstream signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that directly binds to the mTOR complex, inhibiting its activity. Since LOC646864 operates downstream of mTOR, Rapamycin's action results in reduced LOC646864 activity due to the lack of mTOR signaling. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is a selective inhibitor of mTOR that works by blocking both mTORC1 and mTORC2 complexes. By inhibiting these complexes, PP242 disrupts the downstream signaling that would normally result in the activation of LOC646864. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is an ATP-competitive inhibitor of mTOR that effectively blocks the kinase activity of both mTORC1 and mTORC2. This inhibition leads to a decrease in LOC646864 activity by preventing the downstream signaling events required for its function. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is a potent ATP-competitive inhibitor of mTOR that inhibits both mTORC1 and mTORC2 complexes. The inhibition of these complexes leads to a reduction in LOC646864 activity as it is situated downstream of these signaling nodes. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is a highly selective inhibitor of AKT, a serine/threonine-specific protein kinase that plays a key role in the PI3K/AKT/mTOR pathway. AKT inhibition by MK-2206 leads to reduced mTOR signaling and, consequently, reduced LOC646864 activity. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine is an alkylphospholipid that acts as an AKT inhibitor, disrupting the PI3K/AKT/mTOR signaling pathway. The inhibition of AKT results in reduced signaling through mTOR, leading to decreased activity of LOC646864. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
BEZ235 is a dual PI3K/mTOR inhibitor that leads to the blockade of both PI3K and mTOR signaling. By inhibiting these key nodes, BEZ235 reduces the signaling necessary for LOC646864 activity. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
PI-103 is a multi-targeted kinase inhibitor with activity against PI3K and mTOR. By inhibiting these kinases, PI-103 suppresses the signaling pathways upstream of LOC646864, leading to its functional inhibition. | ||||||