LOC644070 Activators
A-769662 and Rolipram exert their influence by modulating AMPK and PDE4 respectively, both of which are involved in the regulation of cAMP, a second messenger with broad implications for protein function. SB 216763 and GSK-3 Inhibitor IX can affect the Wnt/β-catenin signaling pathway by acting on GSK-3β, influencing the activity of proteins involved in cell growth and differentiation. Y-27632's inhibition of ROCK can impact proteins associated with the cytoskeleton and cell motility, while BIX 01294's targeting of histone methyltransferases can alter gene expression profiles, affecting protein levels indirectly. PD0325901 and Puerarin can modulate the MAPK/ERK and PI3K/Akt signaling pathways respectively, influencing the function of a variety of proteins regulated by these pathways.
ZM-447439's action on Aurora kinase affects proteins involved in cell division, and LY294002's inhibition of PI3K influences downstream protein activity in cell survival and proliferation. MG132, by inhibiting the proteasome, can lead to the accumulation of proteins that are normally targeted for degradation, potentially increasing the activity of those proteins. SP600125, through JNK inhibition, can modulate proteins implicated in stress responses and apoptosis.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
Activates AMPK, leading to altered metabolism and protein activity related to energy balance. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Inhibits PDE4, increasing cAMP levels, which can affect protein activity through cAMP-dependent pathways. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
Activates GSK-3β, affecting Wnt signaling and possibly altering the function of proteins in this pathway. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
Inhibits GSK-3β, potentially affecting the Wnt/β-catenin signaling pathway and protein activity therein. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK, which can affect cytoskeleton dynamics and proteins associated with cell shape and motility. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
Inhibits G9a and GLP histone methyltransferases, potentially affecting gene expression and subsequent protein activity. | ||||||
Puerarin | 3681-99-0 | sc-202301 sc-202301A | 5 mg 100 mg | $129.00 $205.00 | 1 | |
Affects various signaling pathways including PI3K/Akt, which can modulate protein activity related to cell survival. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Inhibits Aurora kinase, potentially affecting cell cycle progression and protein activity involved in mitosis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, which can affect the PI3K/Akt pathway and the activity of proteins involved in cell survival and growth. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Inhibits proteasome, potentially leading to increased levels of proteins by preventing their degradation. | ||||||