LOC147646 Inhibitors
LOC147646 inhibitors encompass a diverse array of chemical compounds that indirectly inhibit the functional activity of LOC147646 through interference with specific cellular and biochemical pathways. Hydroxyurea, by reducing the pool of dNTPs, directly impairs DNA synthesis, an essential process for cell division and proliferation.
As LOC147646 is implicated in cell cycle progression, this depletion of dNTPs would hinder its function. Staurosporine's broad kinase inhibition could suppress LOC147646 activity if it operates within kinase-dependent signaling pathways, either by being a substrate of these kinases or by interacting with their targets. Alsterpaullone, as a CDK inhibitor, would prevent the cell cycle from advancing, affecting any LOC147646 activity that is reliant on cell cycle checkpoints. Oligomycin's suppression of ATP synthesis could impede LOC147646's activity if it is ATP-dependent, either for its structural integrity, binding affinities, or catalytic action..Additionally, inhibitors like PD98059 and U0126 could affect LOC147646 by blocking the MAPK/ERK pathway, which may be essential for its activation
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a decrease in deoxyribonucleotide triphosphates (dNTPs) pool, which is crucial for DNA synthesis. LOC147646, being involved in cell cycle progression, would have its function inhibited due to the reduction in DNA synthesis, as the protein's activity is likely tied to the proliferation status of the cell. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting a broad spectrum of kinases, it inadvertently affects kinase-dependent signaling pathways, potentially suppressing the activity of LOC147646 if it is regulated by phosphorylation or if it interacts with proteins that are regulated by such kinases. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor, which impedes cell cycle progression. By inhibiting CDKs, it affects the downstream processes that LOC147646 is involved in, particularly if LOC147646 functions to promote cell cycle progression. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits mitochondrial ATP synthase, reducing cellular ATP levels. LOC147646's function could be inhibited by low ATP levels if it requires ATP for its activity or stability, or if it is part of a cellular process that is ATP-dependent. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which blocks the MAPK/ERK pathway. If LOC147646 is part of this pathway or is regulated by it, its activity would be inhibited as a result of the pathway suppression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, leading to the inhibition of the AKT signaling pathway. If LOC147646's activity is dependent on the AKT pathway for its activation or stabilization, then inhibition of this pathway would result in decreased activity of LOC147646. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi apparatus function, which could inhibit LOC147646 if its function is dependent on Golgi-mediated processes such as protein trafficking or post-translational modification. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to depletion of calcium stores. If LOC147646 requires calcium for its function or is regulated by calcium-dependent proteins, its activity would be inhibited. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs). If LOC147646 interacts with proteins whose stability or activity is regulated by acetylation, its function could be indirectly inhibited when HDAC activity is blocked. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, similar to PD98059, which would lead to inhibition of LOC147646 if its activity is tied to the MAPK/ERK signaling pathway. | ||||||