LOC100041425 Inhibitors
LOC100041425 can contain inhibitors like Staurosporine, LY294002, and PD98059 target kinase activities that are central to protein phosphorylation, a post-translational modification that regulates protein function. The inhibition of kinases can prevent the phosphorylation of proteins, thereby affecting their activity, localization, and interaction with other proteins. The mTOR pathway, a key regulator of cell growth and metabolism, can be modulated by compounds such as Rapamycin. By inhibiting mTOR, Rapamycin can alter protein synthesis and degradation, which may influence the stability and function of a wide array of proteins, including LOC100041425 if it is part of this pathway.
Similarly, the MAPK/ERK and p38 MAP kinase pathways are critical for cell proliferation, differentiation, and the stress response. MEK inhibitors like PD98059 and U0126 would prevent the activation of these pathways, potentially impacting proteins that are regulated by MAPK/ERK signaling. The p38 MAP kinase inhibitor SB203580 would affect the cellular response to stress, which could, in turn, influence the activity of stress-regulated proteins. Inhibitors of cellular processes such as proteasome-mediated degradation (e.g., Bortezomib) and glycolysis (e.g., 2-Deoxy-D-glucose) are also included due to their broad impact on protein turnover and cellular metabolism.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, non-selective inhibitor of protein kinases which could disrupt the phosphorylation state of proteins and potentially alter LOC100041425 activity if it is regulated by phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, which could downregulate PI3K/AKT signaling pathways that may be upstream of LOC100041425. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can modulate the mTOR signaling pathway, potentially affecting proteins that are regulated by this pathway including LOC100041425. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, which might affect LOC100041425 activity if it is regulated by the ERK/MAPK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAP kinase, potentially interfering with stress response pathways that could impinge on LOC100041425 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which may alter the JNK signaling pathway affecting proteins like LOC100041425 if they are part of this pathway. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $219.00 $924.00 | 2 | |
Inhibits IκB kinase, which could affect NF-κB pathway, potentially altering the function of LOC100041425 if it is regulated by NF-κB. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Hedgehog signaling pathway inhibitor, which could indirectly affect LOC100041425 if it is a part of or regulated by the hedgehog pathway. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Inhibits Wnt signaling by preventing the production of Wnt proteins, potentially affecting LOC100041425 if Wnt signaling regulates it. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that can lead to increased cellular stress and potentially influence the degradation process of proteins including LOC100041425. | ||||||