Lingo-1 Activators
Lingo-1 Activators, as a distinct chemical class, primarily revolve around compounds and substances that can influence the activity of the Lingo-1 (Leucine-rich repeat and Ig domain-containing Nogo receptor-interacting protein 1) protein. Lingo-1 is significantly involved in processes related to neurite outgrowth and myelination within the central nervous system. Being a component of a complex that includes the Nogo receptor and other counterparts, it serves as a negative regulator.
For instance, Fingolimod, a modulator of the sphingosine 1-phosphate receptor, can influence the pathways where Lingo-1 is a participant. Similarly, Phorbol 12-myristate is a PKC activator that can impact pathways that regulate myelination and neuronal growth, affecting the Lingo-1 milieu. Nogo-66, a segment of the Nogo-A protein, binds with its receptor in processes that involve Lingo-1. EGF and PDGF, both growth factors, initiate signaling cascades that can intersect with Lingo-1's functional terrain. Ionomycin, by influencing calcium signaling, and Forskolin, by modulating cAMP levels, can both play a role in Lingo-1 associated pathways. Compounds like Genistein, Blebbistatin, and Latrunculin A, by their respective actions on tyrosine kinases, myosin II, and actin polymerization, also stand to influence the broader network where Lingo-1 operates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fingolimod | 162359-55-9 | sc-507334 | 10 mg | $160.00 | ||
A sphingosine 1-phosphate receptor modulator; can indirectly influence pathways involving LINGO1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator; can potentially impact pathways regulating myelination and neuronal growth. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore; calcium signaling can influence LINGO1-associated pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, potentially influencing cAMP levels and pathways involving LINGO1. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Lysophosphatidic acid, involved in signaling which can influence LINGO1 pathways. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
As a cation, might affect various cellular pathways that can indirectly involve LINGO1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor, which can indirectly modulate LINGO1-associated processes. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Affects myosin II and cellular contractility, potentially impacting LINGO1 pathways. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Affects actin polymerization, possibly influencing cellular processes involving LINGO1. | ||||||