LGN Inhibitors
LGN inhibitors include a range of compounds that influence the cellular structures and signaling pathways associated with LGN's role in cell polarity and spindle orientation. Compounds such as Paclitaxel, Nocodazole, Colchicine, Vinblastine, and Vincristine, which target microtubule dynamics, could indirectly decrease LGN activity by disrupting the microtubule structures essential for its function in spindle orientation during mitosis.
In addition to microtubule-targeting agents, compounds like Blebbistatin, ML-7, and Latrunculin A, which affect actin and myosin dynamics, offer indirect methods of inhibiting LGN activity. By altering cell polarity and cytokinesis, these compounds might impact LGN's functional role. Furthermore, Y-27632 and CK-666, by modulating ROCK activity and Arp2/3 complex function, could also indirectly inhibit LGN by affecting cellular processes related to actomyosin contractility and actin filament organization. Moreover, inhibitors like BI-2536 and Monastrol, targeting Plk1 and Eg5 respectively, provide additional avenues for inhibiting LGN. These compounds, by influencing spindle orientation and cell division processes, could indirectly affect LGN's role in these crucial cellular events.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Destabilizes microtubules, potentially inhibiting LGN function by disrupting spindle assembly and cell polarity. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds tubulin and inhibits microtubule polymerization, potentially affecting LGN's role in mitotic spindle orientation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Disrupts microtubule assembly, could indirectly inhibit LGN by altering microtubule dynamics essential for its function. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II, potentially affecting cell polarity and indirectly inhibiting LGN activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase, could disrupt cell polarity and cytokinesis, indirectly inhibiting LGN. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Disrupts actin filaments, potentially affecting cell morphology and indirectly inhibiting LGN's role in cell polarity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor, could indirectly inhibit LGN by affecting actomyosin contractility and cell polarity. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
Inhibits Arp2/3 complex, potentially disrupting actin filament branching and indirectly inhibiting LGN activity in cell polarity. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
Plk1 inhibitor, could affect spindle orientation and cell division, indirectly inhibiting LGN function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits Eg5, potentially disrupting spindle bipolarity and indirectly inhibiting LGN's role in mitotic spindle orientation. | ||||||