LGA Activators
LGA activators are primarily focused on influencing cellular metabolism and energy demands, which in turn might enhance the activity or expression of LGA. β-Estradiol and other hormones like IGF-1 could increase LGA activity indirectly by affecting overall cellular growth, differentiation, and metabolic needs. As cells proliferate or differentiate, the demand for energy and biosynthetic precursors increases, potentially upregulating pathways like glutaminolysis where LGA plays a key role. Similarly, compounds like AICAR, an AMPK activator, and L-leucine, which stimulates the mTOR pathway, are known to upregulate metabolic processes and might thereby increase the activity of enzymes like LGA involved in meeting these enhanced energetic and biosynthetic needs.
Metabolic modulators such as PPARγ agonists and omega-3 fatty acids alter lipid metabolism and overall energy homeostasis, which could lead to a reprogramming of cellular energy pathways, including an increased reliance on glutamine metabolism facilitated by LGA. Spermidine and compounds influencing cellular aging or autophagy might also indirectly enhance LGA activity by affecting protein turnover and cellular rejuvenation processes. Meanwhile, micronutrients like iron, through their essential roles in mitochondrial function and overall metabolism, could influence the activity of enzymes like LGA that are integral to cellular energy production. Collectively, these compounds and conditions represent a multifaceted approach to potentially enhancing LGA activity, reflecting the complexity of metabolic regulation and the interdependence of various pathways in maintaining cellular homeostasis and function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol has been shown to influence energy metabolism and cellular growth in various tissues. It might enhance LGA activity indirectly by affecting cellular metabolism and increasing the demand for glutamine as an energy source. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
PPARγ agonists like Rosiglitazone are known to modulate lipid metabolism and glucose homeostasis. Rosiglitazone might increase LGA expression or activity indirectly by altering metabolic demands and pathways in cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, all trans affects cell differentiation and metabolism. It may influence LGA activity by altering metabolic needs during cell differentiation and development, especially in tissues where LGA is prominently expressed. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AMPK is a key regulator of energy balance within the cell. Activators like AICAR might increase LGA activity by enhancing the cellular energy demand and upregulating pathways like glutaminolysis for energy production. | ||||||
β-Hydroxyisovaleric acid | 625-08-1 | sc-235338 | 5 g | $490.00 | ||
β-Hydroxyisovaleric acid is a metabolite of leucine known to influence muscle metabolism and protein turnover. It might affect LGA activity by altering nitrogen balance and amino acid metabolism in muscle tissue. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
L-leucine is an essential amino acid that can stimulate mTOR signaling, a pathway that regulates cell growth and metabolism. Through mTOR activation, L-leucine might indirectly enhance LGA activity by increasing cellular growth and nutrient demands. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
Omega-3 fatty acids like Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) can modulate inflammation and cellular metabolism. By altering metabolic states, they might indirectly affect LGA activity, particularly in conditions where energy metabolism is shifted or reprogrammed. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol regulates calcium homeostasis and has been implicated in influencing cellular growth and metabolism. It might indirectly affect LGA activity through its role in cellular metabolism and proliferation. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine known for its role in cellular aging and autophagy. By influencing cellular growth and protein turnover, it might affect LGA activity indirectly, particularly in aging cells or cells under autophagic conditions. | ||||||
Iron(II) sulfate solution | 10028-21-4 | sc-224024 | 1 each | $45.00 | ||
Iron is essential for many metabolic processes. Iron (II) sulfate might enhance LGA activity indirectly by affecting mitochondrial function and energy metabolism, where glutaminolysis plays a crucial role. | ||||||