LEO1 Inhibitors
Chemical inhibitors of LEO1 can engage in a variety of cellular mechanisms to achieve functional inhibition. Triptolide and DRB, for instance, target RNA polymerase II, to which LEO1 is closely associated through the PAF1 complex. By inhibiting the transcriptional activity of RNA polymerase II, these compounds can reduce the functional involvement of LEO1 in transcriptional regulation. Flavopiridol inhibits cyclin-dependent kinases that are essential for the phosphorylation of RNA polymerase II, a process that LEO1 is involved in. By limiting phosphorylation, Flavopiridol can disrupt LEO1's role in the transcription process. Similarly, α-Amanitin binds to RNA polymerase II, inhibiting the transcription process and, therefore, LEO1's activity in transcription elongation and chromatin modification. Another inhibitor, ICRF-193, stabilizes the DNA topoisomerase II cleavable complex, which can affect the transcription processes where LEO1 is engaged.
Further, Actinomycin D and Camptothecin disrupt transcription by intercalating into DNA and inhibiting DNA topoisomerase I, respectively, thereby leading to a functional inhibition of LEO1 by halting its transcriptional regulation activities. Cordycepin, as a nucleoside analog, terminates RNA chain elongation and can indirectly inhibit LEO1's role in RNA processing. The kinase inhibitor H7 can alter the phosphorylation state of RNA polymerase II, consequently affecting LEO1 function. MG-132, a proteasome inhibitor, can lead to increased levels of ubiquitinated proteins, potentially affecting LEO1's involvement due to altered protein turnover. Brefeldin A disrupts transport within the cell, influencing the localization and function of transcription regulators and thus LEO1's role. Lastly, Anisomycin inhibits peptidyl transferase activity, which can reduce LEO1's functional activity by limiting the availability of transcription factors necessary for its role in transcription regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide can inhibit the transcriptional activity of RNA polymerase II, which LEO1 is associated with through the PAF1 complex, potentially reducing LEO1's functional involvement in transcriptional regulation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is an adenosine analog that inhibits RNA synthesis by targeting RNA polymerase II, which could indirectly inhibit LEO1 by reducing its associated transcriptional activities. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases (CDKs) which are necessary for the phosphorylation of RNA polymerase II; this could reduce the activity of LEO1 by limiting the phosphorylation-dependent processes it is involved in. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin binds strongly to RNA polymerase II, thus inhibiting the transcription process. This could functionally inhibit LEO1 by preventing it from fulfilling its role in transcription elongation and chromatin modification. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $330.00 $898.00 | 7 | |
ICRF-193 binds to DNA topoisomerase II, stabilizing the cleavable complex and preventing the religation step of the DNA breakage-reunion reaction, which could affect transcription processes where LEO1 is involved. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and prevents RNA synthesis by inhibiting RNA polymerase II, which could lead to functional inhibition of LEO1 by halting its transcriptional regulation activities. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, resulting in the prevention of DNA relegation and potentially affecting transcription processes that LEO1 is involved in. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Cordycepin, a nucleoside analog, terminates RNA chain elongation by inhibiting RNA polymerase, which could indirectly inhibit LEO1's role in RNA processing and transcription elongation. | ||||||
H-7, Dihydrochloride | 108930-17-2 | sc-24009 sc-24009A | 10 mg 50 mg | $80.00 $319.00 | ||
H7 is a broad-spectrum protein kinase inhibitor that could indirectly affect the phosphorylation state of RNA polymerase II, thereby altering LEO1 function in the transcription process. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to increased levels of ubiquitinated proteins, potentially affecting the transcriptional regulation processes that LEO1 is part of due to altered protein turnover. | ||||||