Leiomodin 2 Activators
Leiomodin 2 Activators refers to a class of chemical compounds or substances that are implicated in the activation or modulation of Leiomodin 2 (LMOD2), a protein primarily associated with the regulation of actin dynamics in smooth muscle cells. These activators are crucial in the context of understanding the intricate mechanisms governing actin filament assembly and stability in smooth muscle, which is essential for various physiological processes, including muscle contraction and relaxation. LMOD2 plays a central role in actin polymerization and depolymerization, thereby influencing the contractile behavior of smooth muscle. The chemical compounds falling into the category of LMOD2 activators interact with the cellular pathways or signaling cascades involved in the intricate control of this protein, indirectly influencing its activity and functionality.
LMOD2 activators can encompass a diverse range of molecules that impact the intricate regulatory pathways responsible for modulating actin dynamics in smooth muscle cells. These compounds may target key proteins or kinases involved in the actin cytoskeleton, such as those regulating myosin phosphorylation or calcium signaling. By influencing these pathways, LMOD2 activators indirectly affect the polymerization and depolymerization of actin filaments, thus influencing smooth muscle contraction and relaxation. The identification and characterization of LMOD2 activators are essential for elucidating the precise mechanisms governing smooth muscle biology and its functional role in various physiological processes. Researchers continue to investigate the specific compounds falling within the category of LMOD2 activators and their impacts on smooth muscle biology to uncover new insights into this critical cellular mechanism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a potent Rho kinase (ROCK) inhibitor, indirectly activates Leiomodin 2 (LMOD2) by promoting actin dynamics in smooth muscle cells through ROCK inhibition. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, directly activating protein kinase A (PKA) and subsequently influencing LMOD2 activation. This PKA activation positively impacts LMOD2 in smooth muscle cells by regulating actin dynamics. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a potent activator of protein kinase C (PKC), indirectly triggers the activation of LMOD2 by modulating PKC-dependent signaling pathways that enhance actin dynamics in smooth muscle cells. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, as a calcium channel blocker, indirectly activates LMOD2 by modulating calcium-dependent signaling pathways. This modulation enhances actin dynamics, positively influencing LMOD2 activity in smooth muscle cells. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Sodium Nitroprusside serves as an NO donor, directly activating LMOD2 by modulating cGMP signaling. This activation of cGMP pathways positively impacts LMOD2 activity, contributing to smooth muscle relaxation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, a prostaglandin, indirectly activates LMOD2 by positively influencing actin dynamics through downstream signaling pathways. This enhancement of actin dynamics promotes the activation of LMOD2 in certain contexts. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost, a synthetic prostacyclin (PGI2) analog, indirectly activates LMOD2 by influencing signaling pathways involved in vascular smooth muscle tone. This modulation leads to the activation of LMOD2 and the regulation of actin dynamics. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9, a myosin light chain kinase (MLCK) inhibitor, directly activates LMOD2 by positively influencing actin dynamics. Its regulation of the MLCK-dependent pathway leads to the activation of LMOD2 in smooth muscle cells. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580, a p38 mitogen-activated protein kinase (MAPK) inhibitor, indirectly activates LMOD2 through downstream effects on signaling pathways. By influencing relevant MAPK pathways, it leads to the activation of LMOD2 and regulation of actin dynamics in smooth muscle cells. | ||||||