LECT2 Activators
LECT2 activators are a category of chemicals that engage with the protein Leukocyte Cell-Derived Chemotaxin 2 (LECT2). LECT2 is a multifunctional protein that has been identified as a hepatokine-a signaling molecule secreted by the liver. It is known to participate in various processes including cell signaling and the modulation of immune responses. LECT2 interacts with a variety of cellular receptors and has been implicated in the regulation of neutrophil chemotaxis, implying a role in the immune surveillance and inflammatory response.
Direct activators of LECT2 would likely bind to the protein itself, potentially enhancing its stability or its interaction with specific receptors on the surfaces of target cells. This could involve increasing the affinity of LECT2 for its receptors or preventing its degradation in the extracellular environment, thereby prolonging its biological activity. Such direct binding could also induce conformational changes in LECT2 that promote its functional activity, including its ability to mediate cell signaling pathways or engage with other signaling molecules. Indirect activators of LECT2 may influence the protein in a variety of ways that do not involve direct binding. These could include upregulating the gene expression of LECT2, thereby increasing its production and secretion by the liver. Alternatively, indirect activators might inhibit the action of proteases responsible for degrading LECT2, thus enhancing its presence and activity in the circulation. Other indirect mechanisms could involve the modulation of signaling pathways that influence the release or action of LECT2, or the expression of receptors that interact with LECT2 on the surfaces of target cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
C5a Receptor Antagonist, W-54011 | 405098-33-1 | sc-203863 sc-203863A | 1 mg 5 mg | $206.00 $645.00 | 7 | |
C5a is a potent chemotactic factor that enhances the expression of LECT2. C5a works through the C5aR1-PI3K-AKT pathway, which can enhance LECT2 expression by promoting the nuclear translocation of NF-κB, a transcription factor that binds to the LECT2 promoter. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is a potent inflammatory mediator that also works through the PI3K-AKT pathway. It can enhance the nuclear translocation of NF-κB, leading to enhanced LECT2 expression. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS or lipopolysaccharides are major components of the outer membrane of gram-negative bacteria. LPS can trigger the TLR4-NF-κB pathway, leading to enhanced LECT2 expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide can induce oxidative stress, leading to activation of the NF-κB pathway and subsequent enhancement of LECT2 expression. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide can activate the NF-κB pathway through the involvement of ceramide-activated protein kinases. This activation enhances the expression of LECT2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor. It can enhance LECT2 expression by increasing intracellular calcium levels, which can activate the NF-κB pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP levels can activate PKA, which can enhance the nuclear translocation of NF-κB and subsequent enhancement of LECT2 expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 is a potent and selective inhibitor of NF-κB activation. Despite being an inhibitor, it enhances LECT2 expression by preventing the degradation of IκBα, which allows NF-κB to remain in the nucleus and enhance LECT2 transcription. | ||||||
Zymosan | 9010-72-4 | sc-296863 sc-296863A | 100 mg 1 g | $99.00 $599.00 | 1 | |
Zymosan is a glucan with repeating glucose units, which can stimulate the TLR2-NF-κB pathway, leading to enhanced LECT2 expression. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its receptor H1R, can activate the PI3K-AKT pathway, leading to the nuclear translocation of NF-κB and increased LECT2 expression. | ||||||