Lamin B2 Activators
Lamin B2 is a crucial protein involved in maintaining the structural integrity and organization of the cell nucleus. As a component of the nuclear lamina, Lamin B2 contributes to the stability and function of the nuclear envelope, which encloses the genetic material within the nucleus. The nuclear lamina serves as a scaffold for chromatin organization and provides structural support for various nuclear processes, including DNA replication, transcription, and repair. Lamin B2 plays a pivotal role in regulating nuclear morphology and architecture, influencing cellular functions such as cell division, differentiation, and signaling. Additionally, Lamin B2 is implicated in the tethering of chromatin to the nuclear periphery, facilitating gene expression regulation and genome stability.
Activation of Lamin B2 involves intricate regulatory mechanisms that govern its expression, post-translational modifications, and interactions with other nuclear components. Transcriptional regulation plays a fundamental role in controlling Lamin B2 levels, with various transcription factors and signaling pathways implicated in its expression. Furthermore, post-translational modifications, such as phosphorylation, acetylation, and methylation, dynamically regulate Lamin B2 function and localization within the nucleus. Activation of Lamin B2 may also involve its interaction with other nuclear proteins and complexes, contributing to nuclear envelope organization and function. Overall, elucidating the mechanisms of Lamin B2 activation is crucial for understanding its physiological role in nuclear biology and its implications in cellular processes and disease pathology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that functions as a histone deacetylase (HDAC) inhibitor. By inhibiting HDACs, it can induce histone acetylation, potentially influencing chromatin structure and gene expression, including those related to Lamin B2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased cAMP levels. Elevated cAMP levels can activate protein kinase A (PKA) and influence various cellular processes, potentially impacting the regulation of Lamin B2 through signaling cascades. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
1,25-Dihydroxyvitamin D3 is the active form of vitamin D and acts through the vitamin D receptor (VDR). VDR activation can modulate gene expression, and there is evidence suggesting a potential role in regulating nuclear envelope components such as Lamin B2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent HDAC inhibitor that can influence chromatin remodeling and gene expression. By inhibiting HDACs, it may impact the acetylation status of histones and potentially affect the transcriptional regulation of Lamin B2 and related genes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is a compound that can activate the Wnt/β-catenin signaling pathway. Wnt signaling has been implicated in nuclear envelope dynamics, and activation of this pathway may influence the expression or post-translational modifications of Lamin B2. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) is a compound known for its diverse cellular effects, including the modulation of calcium signaling. As calcium signaling can impact various cellular processes, 2-APB may indirectly influence the regulation of nuclear envelope components such as Lamin B2. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist. PPARγ activation can affect gene expression and cellular processes. There is evidence suggesting a potential link between PPARγ signaling and nuclear envelope dynamics, including Lamin B2 regulation. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $60.00 $165.00 | 6 | |
Carnosic acid is a natural compound with antioxidant properties. It has been reported to modulate cellular redox status. As oxidative stress can impact nuclear envelope integrity, carnosic acid may indirectly influence the dynamics of Lamin B2 through its antioxidant effects. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Sodium valproate is a compound studied in the research of epilepsy. It has been reported to affect histone acetylation and gene expression. The potential impact on chromatin structure and gene regulation suggests a possible role in influencing the expression of nuclear envelope components such as Lamin B2. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cyclic AMP analog that can activate cAMP-dependent signaling pathways. Activation of cAMP-dependent pathways can influence various cellular processes, and there is potential for this compound to modulate the expression or post-translational modifications of Lamin B2. | ||||||