KV1.3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CP 339818 hydrochloride | 185855-91-8 | sc-203903 sc-203903A | 10 mg 50 mg | $155.00 $660.00 | ||
CP 339818 hydrochloride acts as a selective KV1.3 inhibitor, exhibiting a unique binding affinity for the channel's voltage-sensing domains. Its structural conformation allows for precise interactions with critical amino acid residues, stabilizing the inactivated state of the channel. This modulation alters ion flow dynamics, impacting cellular excitability. Additionally, its lipophilic characteristics may enhance membrane permeability, influencing its distribution and interaction with lipid bilayers. | ||||||
Tetraethylammonium acetate tetrahydrate | 67533-12-4 | sc-253665 | 25 g | $65.00 | ||
Blocks the potassium channel by binding to the external mouth of the channel. | ||||||
Charybdotoxin | 95751-30-7 | sc-200979 | 100 µg | $401.00 | 9 | |
Charybdotoxin is a potent inhibitor of KV1.3 channels, characterized by its ability to bind selectively to the channel's pore region. This interaction disrupts potassium ion conductance, leading to altered electrochemical gradients across membranes. The toxin's unique structure facilitates specific hydrogen bonding and hydrophobic interactions with key residues, enhancing its inhibitory efficacy. Its stability in physiological conditions allows for prolonged effects on cellular ion homeostasis, influencing various signaling pathways. | ||||||
Agitoxin | 78207-24-6 | sc-3582 | 5 µg | $94.00 | ||
Agitoxin is a selective KV1.3 channel inhibitor that exhibits a unique binding affinity for the channel's extracellular domain. This interaction stabilizes the closed conformation of the channel, effectively blocking potassium ion flow. The toxin's distinct amino acid composition promotes specific electrostatic interactions with channel residues, enhancing its inhibitory potency. Additionally, Agitoxin's structural rigidity contributes to its resistance against proteolytic degradation, ensuring sustained channel modulation. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
Known to block voltage-gated potassium channels including KV1.3. | ||||||
CDDO Methyl Ester | 218600-53-4 | sc-504720 | 10 mg | $220.00 | ||
Specifically inhibits KV1.3 channels. | ||||||
Psora-4 | 724709-68-6 | sc-253325 | 5 mg | $196.00 | ||
Blocks KV1.3 channels selectively. | ||||||
5-(4-Phenoxybutoxy)psoralen | 870653-45-5 | sc-252247 sc-252247A | 5 mg 25 mg | $118.00 $728.00 | 1 | |
Potent and selective inhibitor of KV1.3 channels. | ||||||
Clofazimine | 2030-63-9 | sc-234402 | 5 g | $198.00 | 6 | |
Known to inhibit KV1.3 channels. | ||||||