Agitoxin (CAS 78207-24-6)
Alternate Names:
Agitoxin-2
Application:
Agitoxin is a small polypeptide, 38 amino acid residues, that acts as a potent inhibitor of the Shaker K+ channel
CAS Number:
78207-24-6
Molecular Weight:
4090.95
Molecular Formula:
C169H278N54O48S8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Agitoxin is a small poly peptide, 38 amino acid residues, that acts as a potent inhibitor of the Shaker K+ channel as well as the mammalian homolog of Shaker. Agitoxin binds to the pore entryway between the subunits of the channel, blocking it from functioning properly; useful as a probe for Kv channel.
Agitoxin (CAS 78207-24-6) References
- Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release. | Suarez-Kurtz, G., et al. 1999. J Pharmacol Exp Ther. 289: 1517-22. PMID: 10336547
- Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels. | Gao, YD. and Garcia, ML. 2003. Proteins. 52: 146-54. PMID: 12833539
- Identification of a voltage-gated potassium channel in gerbil hippocampal mitochondria. | Bednarczyk, P., et al. 2010. Biochem Biophys Res Commun. 397: 614-20. PMID: 20570656
- Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. | Anangi, R., et al. 2012. PLoS One. 7: e52965. PMID: 23300835
- Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies with KcsA-Kv1.6 Channel. | Nekrasova, OV., et al. 2017. J Neuroimmune Pharmacol. 12: 260-276. PMID: 27640211
- High-speed AFM reveals accelerated binding of agitoxin-2 to a K+ channel by induced fit. | Sumino, A., et al. 2019. Sci Adv. 5: eaax0495. PMID: 31281899
- Bioengineered System for High Throughput Screening of Kv1 Ion Channel Blockers. | Sharonov, GV., et al. 2021. Bioengineering (Basel). 8: PMID: 34821753
- Interactions of the Kv1.1 Channel with Peptide Pore Blockers: A Fluorescent Analysis on Mammalian Cells. | Orlov, NA., et al. 2023. Membranes (Basel). 13: PMID: 37505011
- Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. | Garcia, ML., et al. 1994. Biochemistry. 33: 6834-9. PMID: 8204618
- Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. | Krezel, AM., et al. 1995. Protein Sci. 4: 1478-89. PMID: 8520473
Inhibitor of:
KV1.3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Agitoxin, 5 µg | sc-3582 | 5 µg | $94.00 | |||
| US: Only available in the US | ||||||