KLRI2 inhibitors belong to a class of chemical compounds designed to selectively target and interfere with the activity of KLRI2, a protein or molecule associated with immune cell recognition. KLRI2, also known as Klrb1b or Nkrp1b, is a member of the natural killer cell receptor gene family, primarily expressed on the surface of natural killer (NK) cells and certain T cells. These receptors play a pivotal role in immune surveillance by allowing immune cells to recognize specific molecules on target cells, including viruses, tumor cells, and cells under stress.
The primary mechanism of action for KLRI2 inhibitors typically involves their interaction with the KLRI2 protein or its associated molecules, leading to the modulation of receptor function. By inhibiting KLRI2, these compounds have the ability to influence immune cell interactions with target cells, thereby regulating immune responses. However, the specific ligands and signaling pathways associated with KLRI2 are still subjects of active investigation. Scientists studying KLRI2 inhibitors aim to elucidate the precise roles and functions of KLRI2 in immune cell biology, contributing to our understanding of its significance within the context of immune recognition and immune regulation. These inhibitors serve as valuable tools for advancing our knowledge of KLRI2 and its roles in immune surveillance. In this context, they contribute to expanding our understanding of the intricate world of immune receptors and their impact on immune cell function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate inhibits class I histone deacetylases, leading to changes in chromatin structure and potential downregulation of gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and selectively inhibits transcription of genes rich in GC sequences, potentially affecting gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
This compound is a potent inhibitor of RNA polymerase II in eukaryotes, which would lead to a decrease in mRNA synthesis and thus protein expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can raise endosomal pH and may affect the cellular processes for the regulation of gene expression, such as signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a pathway which is often involved in the control of translation and can modulate protein synthesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This compound is a PI3K inhibitor that can disrupt signaling pathways involved in cellular proliferation and gene regulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK), potentially affecting transcription factor activity and gene expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
It inhibits p38 MAP kinase, which is involved in signal transduction pathways that modulate gene expression in response to stress signals. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which may affect the MAPK/ERK pathway and influence gene transcription regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1 and MEK2, affecting the MAPK/ERK signaling pathway and possibly gene expression. | ||||||