KLC2 Activators
KLC2 activators are a unique category of chemicals that can directly or indirectly enhance the activity of KLC2, a protein involved in intracellular transport. These activators function through various signaling pathways that KLC2 is involved in. For instance, Curcumin enhances the JNK signaling pathway which leads to the phosphorylation and activation of KLC2. Also, Resveratrol stimulates the SIRT1 deacetylase that increases the ATPase activity of KLC2. Some activators, like N6-(2-Phenylethyl)adenosine and Berberine, function via the AMPK pathway to enhance the transportation functionality of KLC2.
Other activators work in a more indirect manner, affecting the phosphorylation status of KLC2. Metformin, for example, triggers the AMPK pathway which is known to enhance KLC2's transportation duty. Phosphatidic Acid activates the mTORC1 pathway, while Rapamycin inhibits the same pathway, both affecting the activity of KLC2. Other chemicals such as Staurosporine and LY294002 inhibit various protein kinases, thereby altering the phosphorylation status of KLC2. Finally, activators like Forskolin and Dibutyryl-cAMP work through the cAMP/PKA pathway to stimulate KLC2's transport function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound that activates SIRT1, a NAD+-dependent deacetylase. SIRT1 deacetylation of KLC2 increases its ATPase activity, which enhances its function. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a natural isoquinoline alkaloid that can activate the AMPK pathway, which in turn can increase the activity of KLC2. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporine A inhibits calcineurin, which could potentially lead to an increase in KLC2 activity by affecting its phosphorylation status. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates the cAMP/PKA pathway, which is known to enhance the transportation function of KLC2. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad spectrum protein kinase inhibitor, which can indirectly increase KLC2 activity by influencing its phosphorylation status. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA, which can enhance the transportation function of KLC2. | ||||||