KIF26B Activators
KIF26B, a kinesin protein, is involved in intracellular transport and cell division in addition to playing a role in cell proliferation, migration, and morphogenesis. Certain chemical compounds can enhance KIF26B activity by interacting with these cellular processes and signaling pathways. For instance, Purmorphamine and KAAD-cyclopamine, which affect the Hedgehog signaling pathway, can indirectly activate KIF26B. Compounds like Forskolin could also impact KIF26B activity by increasing intracellular cAMP levels, thereby enhancing motor protein activity or modulating the release of intracellular vesicles. Compounds such as Brefeldin A and Cytochalasin D that disrupt intracellular transport and cytoskeletal organization can also have an impact on KIF26B. Brefeldin A, for example,blocks protein transport from the ER to the Golgi apparatus, which could indirectly affect KIF26B's role in intracellular transport. Cytochalasin D, on the other hand, inhibits actin polymerization, leading to changes in cell movement and division mechanisms that could indirectly affect KIF26B.
Compounds such as Chelerythrine Chloride, Y-27632, SB 431542, ML-7, LY294002, and Rapamycin can also influence KIF26B by affecting cell signaling pathways that interact with the pathways and processes that KIF26B is involved in. Chelerythrine Chloride, a potent inhibitor of protein kinase C (PKC), and LY294002, a potent inhibitor of phosphatidylinositol 3-kinase (PI3K), could indirectly affect KIF26B function by influencing these key cellular pathways. Similarly, Y-27632 and ML-7, which inhibit Rho-associated protein kinases (ROCKs) and myosin light chain kinase (MLCK) respectively, might indirectly activate KIF26B through changes in cell motility and cytoskeletal organization. SB 431542, an inhibitor of TGF-β superfamily type I activin receptor-like kinase receptors, may indirectly affect KIF26B function by impacting the TGF-β pathway. Finally, Rapamycin, an mTOR inhibitor, could alter the autophagy process, which may indirectly affect KIF26B function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Purmorphamine is a small molecule agonist for Smoothened (SMO), a protein involved in the Hedgehog signaling pathway. Given that KIF26B is also involved in this pathway, Purmorphamine could enhance the functional activity of KIF26B by activating this pathway. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
KAAD-cyclopamine is a potent Hedgehog signaling pathway inhibitor by acting on the Smoothened (SMO). Paradoxically, the inhibition of the pathway can decrease negative feedback, leading to the enhancement of KIF26B activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a compound that can increase intracellular cAMP levels. This might indirectly activate KIF26B by enhancing motor protein activity or increasing the release of intracellular vesicles. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C (PKC). PKC is involved in numerous cell signaling pathways that might interact with the pathways KIF26B is involved in. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCKs). ROCKs are involved in cell motility – an indirect activation of KIF26B could occur through changes in cell motility and cytoskeletal organization. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 is a potent and selective inhibitor of transforming growth factor beta superfamily type I activin receptor-like kinase receptors ALK4, ALK5, and ALK7. It may indirectly affect KIF26B function by impacting the TGF-β pathway. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an ADP-ribosylation factor (ARF) guanine nucleotide-exchange protein inhibitor which blocks transport of proteins from the ER to the Golgi apparatus. This can indirectly affect KIF26B’s role in intracellular transport. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, disrupting actin filaments and affecting cell movement and division mechanisms, thereby indirectly affecting KIF26B. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), a key regulator of cellular contraction and motility. This could indirectly affect KIF26B’s role in cell motility. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K). By inhibiting PI3K, it can indirectly affect several signaling pathways that KIF26B may be involved in. | ||||||