KIF25 Activators
Chemical activators of KIF25 include a variety of compounds that interact with microtubules, either stabilizing or destabilizing them, which in turn regulates the activity of this motor protein. Paclitaxel, also known as Taxol, and Epothilone B, for instance, promote the assembly of microtubules, enhancing their stability and consequently leading to the activation of KIF25. This stabilization creates a favorable environment for KIF25 to bind to the microtubules and facilitate its motor function, enabling cellular transport processes. Similarly, compounds like Peloruside A and Laulimalide also support microtubule polymerization, further encouraging the activation of KIF25 by bolstering its interactions with the microtubules, thus promoting its motor activity essential for cellular dynamics.
On the other hand, chemicals such as Nocodazole, Colchicine, Vinblastine, and Vincristine disrupt microtubule polymerization. Nocodazole, specifically, is known to impede microtubule dynamics, which can trigger a compensatory mechanism in the cell, activating KIF25 to overcome the destabilized microtubular network. Colchicine, Vinblastine, and Vincristine, by binding to tubulin, prevent its polymerization into microtubules, indirectly leading to the activation of KIF25 as the cell seeks to adapt to the altered structural landscape. Additionally, Podophyllotoxin and Griseofulvin contribute to this category of compounds, with Podophyllotoxin binding to tubulin and destabilizing microtubules, and Griseofulvin interfering with microtubule assembly, both of which can prompt KIF25 to heighten its activity in response to the compromised microtubule structures. Lastly, 2-Methoxyestradiol, by inhibiting microtubule polymerization, similarly can activate KIF25 to maintain vital cellular transport functions amidst microtubule disruption. Through these diverse interactions with microtubules, each of these compounds can modulate the activity of KIF25, reflecting the protein's integral role in cellular transport and structural integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can enhance the microtubule binding activity of KIF25, leading to its functional activation as it operates as a microtubule-dependent motor protein. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization dynamics. The response of KIF25 to stabilize and transport along microtubule structures can be activated in the presence of nocodazole as the protein works to counteract the destabilization, thereby activating KIF25's motor function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, indirectly necessitating the activation of microtubule-associated proteins like KIF25 to mediate cellular responses to altered microtubule dynamics. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine inhibits microtubule formation by binding to tubulin, which can activate KIF25 by creating a cellular condition that requires the microtubule-dependent motor activity of KIF25 for cell adaptation and survival. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B functions similarly to paclitaxel by stabilizing microtubules, which can activate KIF25 by promoting its association with microtubules and enhancing its motor activity, as it would be required to transport cellular components along these stabilized structures. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin destabilizes microtubules by binding to tubulin, which can activate KIF25 to interact with the destabilized microtubules, possibly to attempt to maintain cellular transport and structure. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide also promotes microtubule polymerization and can activate KIF25 by driving its microtubule-dependent motor activity, as the protein responds to the increased microtubule stability and engages in its transport function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interfering with microtubule assembly. This disruption can activate KIF25, which may be called upon to enhance its motor activity in response to the compromised microtubule dynamics. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol binds to microtubules and inhibits their polymerization. This action can activate KIF25 as the protein might increase its motor activity to deal with the effects of microtubule destabilization, thereby facilitating continued cellular transport functions in the face of microtubule disruption. | ||||||