K12 Activators
K12 Activators are a group of chemical compounds that indirectly influence the expression and function of keratin type I cytoskeletal 12 by acting on various cellular pathways and conditions necessary for keratin synthesis and stability. They range from vitamins and minerals that provide essential nutrients and cofactors to bioactive compounds that modulate gene expression and cellular stress responses.
These activators include retinoic acid, which can enhance gene expression by interacting with nuclear receptors; EGCG, which activates NRF2 and increases the expression of cytoprotective genes including keratins; and calcium ions, which are pivotal in keratinocyte differentiation and keratin synthesis. Trace elements like zinc and selenium contribute to the structural integrity and antioxidant defense of keratinocytes, thereby supporting K12 expression. Vitamins and related nutrients such as niacinamide, biotin, and D-panthenol play roles in maintaining skin barrier function and cellular growth, processes that are essential for keratin protein synthesis. Amino acids like L-cysteine and methionine serve as direct precursors for keratin production. Finally, antioxidant compounds such as vitamin E protect keratinocytes from oxidative stress, ensuring optimal conditions for K12 expression. Copper peptides have been found to stimulate the production and repair processes in skin cells, leading to increased keratin production.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence keratin gene expression by binding to nuclear receptors and modulating transcriptional processes, thus potentially upregulating the expression of K12. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can activate NRF2, a transcription factor that regulates the expression of protective cytoprotective genes, which may include keratins like K12 under conditions of oxidative stress. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions play a significant role in keratinocyte differentiation, which can lead to increased synthesis of keratins such as K12. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is essential for the proper function of numerous enzymes and it may play a role in keratinocyte differentiation and the expression of keratins, including K12. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium is crucial for antioxidant defense mechanisms and may aid in maintaining keratinocyte health, potentially influencing K12 expression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Niacinamide can support skin barrier function and is involved in the synthesis of keratinocytes, which may upregulate keratin proteins like K12. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $51.00 $112.00 $449.00 $1151.00 $2178.00 | 1 | |
As a sulfur-containing amino acid, L-Cysteine is a building block of keratins and its supplementation can support the synthesis of keratin proteins such as K12. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine, another sulfur-containing amino acid, is a precursor in keratin synthesis and can thus support the production of K12. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Vitamin E can protect keratinocytes from oxidative damage, thus preserving their function and possibly influencing the expression of keratins like K12. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
Biotin is important for cellular growth and the synthesis of keratin, and it may therefore support the production of K12. | ||||||